CATALINA ZAHARIA (AVRAM), DRAGOS ACATRINEI, CARMEN GENTIMIR(AMITITELOAIE), OTILIA BOISTEANU, CRISTINA OANA RADUCANU, LILIANA CHELARU, DECEBAL VASINCU, GEANINA BOGZA, MARCEL COSTULEANU<br>Biochemical Effects of Some Endoplasmic Reticulum <br>Stressors and pre-B Lymphocytes Apoptosis

CATALINA ZAHARIA (AVRAM), DRAGOS ACATRINEI, CARMEN GENTIMIR(AMITITELOAIE), OTILIA BOISTEANU, CRISTINA OANA RADUCANU, LILIANA CHELARU, DECEBAL VASINCU, GEANINA BOGZA, MARCEL COSTULEANU
Biochemical Effects of Some Endoplasmic Reticulum
Stressors and pre-B Lymphocytes Apoptosis

Abstract:

Tunicamycin is a powerful endoplasmic reticulum stressor. Endoplasmic reticulum stress reflects the accumulation of unfolded proteins and is followed by the activation of Unfolded Protein Response (UPR). The effects of tunicamycin are related to its capacity to inhibit the protein N-glycosylation. This moment, there are few data concerning the importance and mechanisms of pre-B cells apoptosis induced by tunicamycin. In our study, tunicamycin induced apoptosis in a large number of isolated murine pre-B cells. Its apoptotic effects were less extensive than those induced by valinomycin, affecting almost all cultured pre-B cells. On the other hand, thapsigargin, a well known endoplasmic reticulum Ca2+ disruptor and stressor had no significant apoptotic effects in pre-B cells. The mechanisms underlying the apoptotic effects of tunicamycin in pre-B cells remain to be studied in depth by future approaches. Keywords: tunicamycin, thapsigargin, pre-B cells, apoptosis

Issue: 2015, Volume 66, Issue 12

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