RODICA NARCISA TANASESCU,  ADRIANA FULIAS, IONUT LEDETI, MARIANA  IOANA MIRON, PETRU MATUSZ<br>Evaluation of Mineral Composition in the Area of the Cortical Osteoporotic Bone: a Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electronic Microscopy (SEM) Study

RODICA NARCISA TANASESCU, ADRIANA FULIAS, IONUT LEDETI, MARIANA IOANA MIRON, PETRU MATUSZ
Evaluation of Mineral Composition in the Area of the Cortical Osteoporotic Bone: a Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electronic Microscopy (SEM) Study

Abstract:

Osteoporotic bone is a composite material consisting of a mineral phase (hydroxyapatite), an organic matrix (collagen), in combination with noncollagenous proteins, lipids and water. Patients with postmenopausal osteoporosis experience often bone fractures due to defective mineralization, altered bone turnover and poor remodeling rate. The aim of this case-control experimental study performed on 44 eligible women was to highlight the mineral component variability in the cortical bone by testing the hypothesis that fracture fixation osteoporotic bone has an increased crystallinity and reduced heterogenic texture when compared with the non-osteoporotic one. Qualitative and structural information relating to biological (poorly crystalline) hydroxyapatite was revealed by FTIR spectroscopy in thin sections obtained from osteoporotic bone biopsies. Correlations were noted between spectral parameters and crystal size as determined by SEM. The applications of these structural complementary methods revealed specific variations in the cortical area based on change of the phosphate í1 and í2 absorbances in the 900-1200 cm-1 most interesting spectral region. The results of this study performed on cortical osteoporotic bone reveal structural and compositional information of the newly deposited mineral bone component in osteoporotic patients. These data allow the correlation of the cortical mineral properties with bone quality and have implications on osteoporotic treatments. Keywords: postmenopausal osteoporosis, cortical mineral bone, hydroxyapatite, crystal size, spatial distribution, Fourier Transform Infrared Spectroscopy (FTIR); Scanning Electron Microscopy (SEM)

Issue: 2015, Volume 66, Issue 12

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