EOSEFINA GINA BOTNARIU, NORINA CONSUELA FORNA, ALINA DELIA POPA, ILEANA ANTOHE, CRISTINA LACATUSU, BOGDAN MIHAI<br>Presepsin as a Biomarker for Sepsis Evolutions in Diabetis

EOSEFINA GINA BOTNARIU, NORINA CONSUELA FORNA, ALINA DELIA POPA, ILEANA ANTOHE, CRISTINA LACATUSU, BOGDAN MIHAI
Presepsin as a Biomarker for Sepsis Evolutions in Diabetis

Abstract:

The paper presents the correlations between seric presepsin value and evolutive aspects (especially mortality) in diabetic patients with sepsis. The study included a total of 60 patients with a mean age of 64.65 ± 12.99 years, (Male = 51.6 %, Female = 48.4%), consecutively hospitalized in the Clinic of Diabetes, Nutrition and Metabolic Diseases in 1 year (2013), with diagnosis of sepsis. We selected the patients who fulfilled at least 2 criterions for sepsis: suspected or proved infection, together with system inflammatory response. The presepsin determination was performed by using a chemiluminescent enzyme immunoassay of EDTA (Ethylenediaminetetraacetic acid) plasma. The clinical evolution was expected by calculating SAPS II score (Simplified Acute Physiology Score) in first 24 hours of internship.The median age was 64.65 ± 12.99 years, Male = 51.6%. Diabetic keto-acidosis was associated to sepsis in 32.3% of patients. Mortality rate was 32.3%. There were semnificative correlations between mortality rate and SAPS II score (p = 0.001), presepsine (p = 0.001), and fibrinogen value (p = 0.048). There were no semnificative correlations between age, sex, keto-acidosis, another inflammatory markers, glycemia, HbA1c and mortality rate in these patients. Presepsin level in blood semnificative correlated with seric fibrinogen, mortality rate, SAPS II score, blood urea and creatinine and may be considered an important serum biomarker for early detection of sepsis. Keywords: presepsine, glycemia, keto-acidosis, biomarker, blood urea

Issue: 2015, Volume 66, Issue 12

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