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REVISTA DE CHIMIE
https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie, Volume 54, Issue 1, pp. (2003)




The Stability/Valability Prediction of Some Drugs Lucia Ciohodaru

Abstract:

In order to predict the stability at shelf storage ( shelf life ) or at any another desired temperature and to calculate the expiration date of some drugs, the method of accelerated ageing was applied - by using the non-isothermal kinetics. Temperature of the systems was raised according to a predetermined non-linear programme temperature-time. Experimentations and stability/ accelerated studies were performed for two very different kinds of drugs: sulphafurazole- conditioned as parenteral ampoules - and ampicillin - conditioned as suspendable powder. At present, it is considered that such method is a useful mean for quality assurance of drugs and, also, in this way it could be avoid the very long times required for determinations in usual conditions preservation or using isothermal kinetics. Keywords: stability prediction of drugs; expiration date of drugs; accelerated ageing method; non-isothermal kinetics

Issue: 2003 Volume 54, Number 1
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