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Revista de Chimie, Volume 67, Issue 1, pp. (2016)




DRAGOS ACATRINEI, CARMEN GENTIMIR (AMITITELOAIE), CATALINA ZAHARIA (AVRAM), CRISTINA OANA RADUCANU,GEANINA BOGZA, LILIANA CHELARU, DECEBAL VASINCU, OTILIA BOISTEANU, MARCEL COSTULEANU Relationships of NR4A1 Agonists Biochemical Effects with Pre-B Lymphocytes Apoptosis

Abstract:

Cytosporone B (Csn-B) is the known natural agonist of NR4A1/Nur77 orphan nuclear receptor. In our study, Csn-B failed to induce important apoptosis in isolated mouse pre-B cells, although used in high concentrations (100 mM) and for long time (24 h). Retinoid X receptors (RXRs) form heterodimers with NR4A1 ones, although the role of such complexes remain unidentified. 9-cis retinoic acid (9 -CRA), the agonist for RXRs, is showing a very similar effect to Csn-B concerning the apoptosis of mouse pre-B cells. The treatment with both molecules could increase in a significant, although reduced manner, the amount of apoptosis in pre-B cells. Further studies are needed to describe the mechanisms underlying such apoptotic effects. Keywords: Cytosporone B, 9-cis retinoic acid, pre-B cells, apoptosis

Issue: 2016 Volume 67, Number 1
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