The Study of VHB Genotypes in a  Population / a Pilot Study

Luca, Andrei Stefan; Luca, Mihaela Catalina; Ursu, Ramona Gabriela; Iancu, Luminita Smaranda

Andrei Stefan Luca, Mihaela Catalina Luca, Ramona Gabriela Ursu, Luminita Smaranda Iancu

The Study of VHB Genotypes in a Population / a Pilot Study

Abstract:

Identifying the hepatitis B virus (HBV) genotype is crucial for hepatocellular carcinoma (HCC) surveillance related to HBV infection. The aim of this pilot study was to evaluate the prevalence of HBV genotypes at the patients with chronic hepatitis in the N-E region of the country. Material and Method: 20 patients with chronic hepatitis B virus were included in this study during July-October 2014 period and were tested for serological markers (chemiluminiscence assay, viral load (Real Time PCR assay) and genotyping method. We detected the D genotype of HBV in 19 (95%) of the patients; one had only genotype A (5%) like unique infection, and in other case was diagnosed two associated genotipes, A and D(5%) We found statistical significant difference among the mean of viremia (DNA/HBV) and the genotype of HBV (p=0.004) , the presence / absence of HBeAg and antiHBe (p=0.001), the severity of fibrosis(p=0.006), and the presence / absence of interferon therapy (p=0.001). The D genotype of HBV is the most frequent in our area, alone or associated with A genotype. Genotyping of HBV should be routinely introduced in our hospital, as our data suggest that testing patients for serological markers and viral load in association with the HBV type is very useful for monitorization of chronic B hepatitits patients.

Keywords:
HBV; genotype; INNOLiPA; HBeAg negativ; antiviral therapy

Issue: 2016, Volume 67, Issue 3

Pages:

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This article is published under the Creative Commons Attribution 4.0 International License

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