Strontium Ranelate Effects on Inorganic Bone Grafts in Maxillary Sinus Floor Augmentation

Dragan, Eliza; Odri, Guillaume A.; Benchea, Marcelin; Ferariu, Dan; Eloae, Florin Zugun; Geletu, Gabriela; Galesanu1, Corina; Haba, Danisia; Melian, Gabriel

Eliza Dragan, Guillaume A. Odri, Marcelin Benchea, Dan Ferariu, Florin Zugun Eloae, Gabriela Geletu, Corina Galesanu1, Danisia Haba, Gabriel Melian

Strontium Ranelate Effects on Inorganic Bone Grafts in Maxillary Sinus Floor Augmentation

Abstract:

The maxillary sinus floor augmentation surgery is one of the techniques of restoration of bone quantity of the superior maxilla in partially or totally edentulous patients. However this technique could be associated with delays for final implant placement. Depending on the height of the residual bone, the period of osseointegration varies between 6 and 12 months. Therefore the aim of our study was to investigate if strontium ranelate improves osseointegration of maxillary sinus bone xenograft. Two surgery interventions (maxillary sinus augmentation) were performed on the same patient, at an interval of 6 months between them. The patient received strontium ranelate (Osseor, Servier Pharma, 2g/day, for 6 months) only after the first surgery. Cone-Beam CT exam (CBCT) of the maxilla was performed after each stage. After each surgery intervention including a 6-month healing period, the implants were inserted and bone core was harvested from both maxillary sinuses. The bone core was sent for histologic examination, automatic nuclear segmentation and microindentation tests. The results of the tests (histologic analysis, automatic nuclear segmentation and microindentation tests) were compared. We found out that the antiosteoporotic agent improved bone microarchitecture and bone mechanical properties. This study demonstrates that the osseointegration of the innorganic bovine bone graft can be influenced by Strontium ranelate (Osseor).

Keywords:
bone graft; microindentation tests; automatic nuclear segmentation; strontium ranelate; sinus augmentation

Issue: 2016, Volume 67, Issue 3

Pages:

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This article is published under the Creative Commons Attribution 4.0 International License

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