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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2016, Volume 67, Issue 3,



Oana Elena Ciurcanu, O. Stefanescu, Monica Mihaela Scutariu, Carmen Gabriela Stelea

Importance of the Chemistry of Local Anesthetic in Modulation of Cardio-vascular Response

Abstract:

Local anesthetics are chemical substances which depress reversibly, temporary and specifically the sensibility and transmission of nervous impulses of pain. To reach the nervous fiber, the local anesthetic must propagate from the administration point to the area where it will exercise the specific effect. After the deposit, a part of it will bind to nonspecific tissue (conjunctive tissue, fat, muscular fibers), another part is absorbed into the blood and just a small fraction is transported to the nervous tissue. Once it has entered circulation, the local anesthetic binds partially (5 to 95%) to plasma proteins, in particular to acid alpha 1-glycoprotein (and less to albumin) and a part circulates freely. Because alpha 1-glycoprotein transports other drugs: betablockers (propanolol), blockers of calcium ions (verapamil), antiarrhythmics (quinidine), the fraction unbound by local anesthetic in cardiovascular patients will increase in circulation and it can determine serious general accidents of overdose, interpreted as accidents of intolerance, allergic.

Keywords:
ALR; epinephrine; cardiovascular constants; vasoconstrictor

Issue: 2016, Volume 67, Issue 3
Pages:
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