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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2016, Volume 67, Issue 3,



Anca Mihaela Mocanu, Constantin Luca, Ion Sandu, Simona Isabela Dunca

Synthesis, Characterization and Evaluation Antimicrobial Activity of Some New Derivatives Theophylline Sulfonyl Phenoxyacetic Acids

Abstract:

The purpose of this study is to synthesis and assess antibacterial activity of new derivates of theophylline-sulphonyl phenoxyacetic acids. The compounds were obtained by hydrazides condensation of the acids with a series of alheides. Due to the biologically activity found for previously known theophylline-sulphonyl phenoxyacetic acids we considered opportune to synthesize and characterize new compounds of the same class. The synthesis stages of the new products (azomethine) are presented as well as the elemental analysis data and IR, 1H-RMN spectral measurements made for elucidating the chemical structures, and microbial properties were confirmed by the microbiological tests. The synthetized compounds were evaluated taking into account their microbial activity, in vitro, by measuring zone diameters of bacterial growth inhibition of two different types of strains microorganisms: Pseudomonas aeruginosa ’and Escherichia coli.

Keywords:
hydrazide; azomethine; spectral measurements; microbiological tests; antimicrobial activity

Issue: 2016, Volume 67, Issue 3
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