GRIGORE TINICA, RALUCA OZANA CHISTOL, MARIA MAGDALENA LEON CONSTANTIN, ANISIA IULIANA ALEXA, STEFAN CONSTANTIN, CRISTINA FURNICA<br>N-acetylcysteine for Prevention of Postoperative Renal Failure

GRIGORE TINICA, RALUCA OZANA CHISTOL, MARIA MAGDALENA LEON CONSTANTIN, ANISIA IULIANA ALEXA, STEFAN CONSTANTIN, CRISTINA FURNICA
N-acetylcysteine for Prevention of Postoperative Renal Failure

Abstract:

Several pharmaceutical agents have been proposed as protective factors against acute renal failure, from which N-acetylcysteine gained a particular interest. The aim of the current research is to evaluate NAC ability of preventing ARF in patients with chronic kidney disease (CKD) undergoing coronary artery bypass grafting (CABG). The authors analyzed 92 patients with preoperative CKD that benefited from CABG between 2000-2010. 44 of the 92 patients received intravenous NAC immediately after cardiopulmonary bypass cessation while the remaining 48 patients did not receive any particular medication. Postoperatively, estimated glomerular filtration ratio (eGFR) decreased with 14.73% in patients that did not receive NAC and with 13.1% in patients that received NAC (p = 0.07). From the 14 patients that required hemodialysis, 6 received NAC (13.67%) and 8 did non receive NAC (16.67%) (p = 0.55). ICU admission was similar for the two groups of patients (8.71 days in NAC group and 8.52 days in the no NAC group) (p = 0.15). The 2 patients with CKD that did not survive the first 30 days were not treated with NAC. No adverse effects to NAC and no statistically significant difference concerning the incidence of postoperative complications were noticed in the study group. Thus, the results of the current study suggest that NAC administration in patients with CKD brings little to no benefit in the prevention of postoperative ARF. Keywords: N-acetylcysteine, pharmaceutical agents, oxidative stress, glutathione, cysteine, estimated glomerular filtration ratio

Issue: 2016, Volume 67, Issue 5

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