NICOLETA DIMA, ELENA REZUS, ANA MARIA SINGEAP, ANCA TRIFAN, CIPRIAN REZUS<br>Analysis of Enzymatic Systems in the Severe Hepatic Dysfunction

NICOLETA DIMA, ELENA REZUS, ANA MARIA SINGEAP, ANCA TRIFAN, CIPRIAN REZUS
Analysis of Enzymatic Systems in the Severe Hepatic Dysfunction

Abstract:

Cirrhosis of liver, an irreversible and diffuse affection of the liver, is an important cause for morbidity and mortality on a national and international level, with a great impact on patients, on their families, on the sanitary system, on society and economy. The main objective of the study was the assessment of the enzymatic profile and argumentation of the important role of alcoholism has in patients with cirrhosis of the liver. We have performed and observational and prospective study which included 389 patients diagnosed with cirrhosis of the liver, admitted within the Institute of Gastroenterology and Hepatology from Iasi. On the studied group, the average age of the patients was 54.23±5.54 years, with the predominance of the males, representing 65.32% of the total of the patients included in the study. Using the Baveno IV criteria at the registration in the study, from the 389 patients, 152 were in the compensated cirrhosis of the liver stage (39.23%), and 60.77% in the decompensated cirrhosis of the liver stage (237) patients. From an etiologic point of view, 158 patients (40.68%) have presented viral etiology, 59.32% toxic (231 patients) out of which 23.36% viral and toxic etiology. The average CAGE result in patients with ethanol etiology was of 2.177, confirming alcoholism, a systemic affection by the complexity of clinical manifestations with common etiopathogenic basis. Ethanol etiology is predominant, an alarming fact being its presence under 40 years, the implementation of national programs addressed to the young and active population being useful, even necessary. The indirect serological markers may be correlated with fibrosis, but don’t typically characterize the fibrogenic biological processes, mostly evaluating the hepatic function and not the metabolism of the extracellular matrix. It presents the advantage of decreased cost and technical facilities. In the patients included in the study, the average ASAT value was of 111.22±7.42 U/L, with limits between 46 and 179 exceeding the values of the healthy individuals (p [ 0,001) by 3.53 times, and the ALAT value was of 64.65±6.12 U/L (limits between 39 and 198). In a period in which we are witnessing an explosive medical progress, the discovery of serological markers which observe as many criteria of an ideal marker would be of real support in the management of the cirrhosis of the liver. Using these markers could also have an anticipation value through monitoring in dynamics, optimizing the protocols of clinical studies and assessing the efficiency of therapeutic agents. Keywords: ethanol, enzymatic markers, cirrhosis of the liver, Baveno IV staging

Issue: 2016, Volume 67, Issue 5

Pages:

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)