OVIDIU MITU, FLORIN MITU, MARIA MAGDALENA LEON CONSTANTIN, MIHAI ROCA, ANDREEA GHERASIM, MARIANA GRAUR<br>Biochemical Changes in Asymptomatic Adult Population <br>with Subclinical Atherosclerosis

OVIDIU MITU, FLORIN MITU, MARIA MAGDALENA LEON CONSTANTIN, MIHAI ROCA, ANDREEA GHERASIM, MARIANA GRAUR
Biochemical Changes in Asymptomatic Adult Population
with Subclinical Atherosclerosis

Abstract:

In cardiovascular (CV) prevention, the accurate risk evaluation of patients without clinical CV diseases requires multiple investigations, both biochemical and imagistic. This study presents the correlations between various biochemical markers and different parameters of subclinical atherosclerosis assessed in a group of asymptomatic population. Over a 2-year period, 120 subjects were randomized and comprehensively evaluated, with a mean age of 52.01 ± 10.73 years, 66.66% being female. Out of all biochemical markers, the lipid parameters reached the superior limit: total cholesterol (209.77 ± 45.56 mg%), LDL cholesterol (129.96 ± 40.71 mg%) and non-HDL cholesterol (157.27 ± 44.89 mg%). By gender, women presented increased values of fibrinogen, as marker of inflammation (p=0.031) while plasma glucose, uric acid and triglycerides were significantly higher in men (p=0.01; p[0.001; p=0.043). Most of the biochemical markers correlated positively with aging. Non-HDL and total cholesterol were associated significantly with intima-media thickness (IMT) (r=0.22, p=0.013; r=0.23, p=0.009), pulse wave velocity (PWV) (r=0.28, p=0.003; r=0.30, p=0.001) and the presence of aortic atheromatosis (p=0.001; p=0.002) and carotid plaques (p=0.001; p[0.001). Increased left ventricular mass index correlated with hypertriglyceridemia (r=0.18, p=0.047). Uric acid presented significant relation with all markers of subclinical atherosclerosis. A decreased renal function was associated with high IMT (r=-0.22, p=0.015), PWV (r=-0.29, p=0.002), carotid plaques (p[0.001) and aortic atheromatosis (p[0.001). Plasma glucose and hepatic markers presented insignificant correlations. Thus, in asymptomatic patients, the biochemical assessment may provide incremental value for the atherosclerotic burden of each individual. Keywords: biochemical markers, subclinical atherosclerosis, asymptomatic, cardiovascular

Issue: 2016, Volume 67, Issue 5

Pages:

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)