DAN NAVOLAN, MIHAELA CRACIUNESCU, IOANA CIOHAT, DANA STOIAN, DIANA BADIU, MARIUS CRAINA, FLORIN BIRSASTEANU, DRAGOS NEMESCU, SIMONA VLADAREANU<br>The Influence of Some Biological Markers in Early Pregnancy <br>of Patients with Birth at Term and Preterm Birth

DAN NAVOLAN, MIHAELA CRACIUNESCU, IOANA CIOHAT, DANA STOIAN, DIANA BADIU, MARIUS CRAINA, FLORIN BIRSASTEANU, DRAGOS NEMESCU, SIMONA VLADAREANU
The Influence of Some Biological Markers in Early Pregnancy
of Patients with Birth at Term and Preterm Birth

Abstract:

The objective of this study was to analyze the influence of C reactive protein (CRP) and CRP/Creatinine (CRE) ratio in early pregnancy of pregnant women with birth at term (BT) and preterm birth (PB) and to analyze if CRP or CRP/CRE could discriminate between BT and PB. CRP and CRE were measured in 80 sera sampled from 40 pregnancies with BT and 36 sera from 18 pregnancies with PB: one sera sampled in the first and another in the second trimester. Early pregnancy CRP and CRP/CRE showed a direct correlation with gestational age (GA): CRP (rho=0.21, p=0.025), CRP/CRE (rho=0.27, p=0.003). The correlations were present in both groups (BT and PB), but reached a significant value only for CRP/CRE. No difference was found between CRP and CRP/CRE concentrations in sera of pregnant women with BT and PB when first or second sera were analyzed. CRP/CRE better correlate with GA than CRP. Both early pregnancy concentrations of CRP or CRP/CRE ratio, could not discriminate between BT and PB patients in sera collected 6-10 weeks before symptoms occur. Keywords: Preterm birth, early pregnancy, C-reactive protein, creatinine

Issue: 2016, Volume 67, Issue 5

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