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Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
ISSN Online 2668-8212
ISSN Print: 1582-9049
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Revista de Chimie (Rev. Chim.), Year 2016, Volume 67, Issue 9,





ALINA CANTEMIR, ANISIA IULIANA ALEXA, ALIN CIOBICA, ELENA TOADER, IOANA MIRUNA BALMUS, SABINA IOANA COJOCARU, DORIN CHISELITA, DANUT COSTIN
The Pathological Relevance of Some Biochemical Changes in Keratoconus Focusing on serum lipid peroxidation products

Abstract:

Keratoconus (KC) is one of the most common degenerative corneal diseases. It is known that during KC degeneration the cornea gains conical shape and layers thinning, involving several molecular factors changes many of which consist in local or blood stream components. Furthermore, growing evidence show key implication of oxidative stress in degenerative processes observed in KC patients. In this way, malondialdehyde serum levels screening was made in order to find correlations between KC patients and controls. It has been shown that serum malondialdehyde (as a lipid peroxidation marker) level is increased in KC patients. Furthermore, we showed a decrease in lipid peroxidation levels during the monitoring time. These changes would indicate that an inflammatory process may be involved in keratoconus, but further analysis is needed. Keywords: malondialdehyde, thiobarbituric acid reactive substances, blood, keratoconus


Issue: 2016, Volume 67, Issue 9
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