ROMEO DOBRIN, ALIN CIOBICA, ELENA TOADER, VLADIMIR POROCH<br>The Influence of Spiperone on Oxidative Stress and Memory

ROMEO DOBRIN, ALIN CIOBICA, ELENA TOADER, VLADIMIR POROCH
The Influence of Spiperone on Oxidative Stress and Memory

Abstract:

Memory is a cognitive domain showing various deficits in schizophrenia. Spiperone, a potent D2-like receptor antagonist, is also a typical antipsychotic belonging to the butyrophenone chemical class, which is licensed for clinical use in some countries for the treatment of schizophrenia. However, very few studies in the literature used spiperone for the blockade of the dopaminergic system. In this way, considering these very few information about the effects of spiperone on memory processes and also on oxidative stress status, we decided to study the effects of spiperone (0.4 mg/kg body weight) pre-testing intraperitoneally administration in normal rats on spontaneous alternation behavior and number of arm entries in Y-maze task and the latency time in the passive avoidance performance. Also, we were interested in seeing the effects of spiperone administration on the oxidative stress status from the hippocampus, by assessing two antioxidant enzymes: superoxide dismutase-SOD and glutathione peroxidase-GPX, as well as a lipid peroxidation marker: malondialdehyde-MDA. The administration of spiperone impaired memory processes in normal rats (especially a significant decrease of the latency time on both 24 and 72 h in pre-test spiperone treated rats, as compared to the control group), while also generating increased levels of lipid peroxidation markers such as MDA and decreased enzymatic antioxidants in the hippocampus. Moreover, we found significant correlations between the behavioral parameters we determined in the passive avoidance tasks and the levels of all oxidative stress markers which we determined, as a result o spiperone administration. Keywords: spiperone, superoxide dismutase, gluthatione peroxidase, oxidative stress, memory

Issue: 2016, Volume 67, Issue 9

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