Ana Minodora Grozdan, Rodica Ghiuru, Corneliu Botez, Cristina Maria Gavrilescu, Odetta Duma, Catalin Buzduga, Costinela Georgescu, Liliana Strat, Dragos Munteanu<br>Correlations Between Cardiovascular/Cardiometabolic Risk <br>and Standard Biochemical Investigations

Ana Minodora Grozdan, Rodica Ghiuru, Corneliu Botez, Cristina Maria Gavrilescu, Odetta Duma, Catalin Buzduga, Costinela Georgescu, Liliana Strat, Dragos Munteanu
Correlations Between Cardiovascular/Cardiometabolic Risk
and Standard Biochemical Investigations

Abstract:

The metabolic syndrome is a pathologic constellation which brings negative effects on the heart, mainly by an atherosclerosis mechanism. Obesity, as a first rank component of the metabolic syndrome, leads to many imbalances of the cardiac function, respectively neurohormonal activation with hypervolemia, apoptosis, fibrosis, and hypertrophy, triggered by the proinflammatory adipocytokines, associated with the lypotoxic effect of the fats of myocardial cells. Arterial hypertension can lead to left ventricular hypertrophy, but it can also occur in obese people, independently from arterial hypertension. Initially concentric, it evolves into non-concentric, being associated with diastolic dysfunction, left atrial enlargement, right ventricular enlargement and hypertrophy, etc. There have been attempts to define the relation between obesity, cardiovascular diseases and standard biochemical investigations, observing the direct relation between these clinical - pathological variables and the changes of paraclinical parameters, frequently used and studied in medical practice. The retrospective randomized double-blind study was conducted on a 2 years’ period of time, between 2013 and 2014, and included 2 individualized groups, one that included patients with metabolic syndrome, clinically and functionally investigated, and a control group, subject to the same evaluations. Thus, it was useful to re-introduce a basic package of routine evaluation investigations. The purpose of this biochemical evaluation is the medium- and long-term prophylaxis of MS, respectively of the four components, HTN, dyslipidemia syndrome, sugar diabetes, and obesity. Keywords: atherosclerosis mechanism, metabolic syndrome, hypervolemia, apoptosis, fibrosis, hypertrophy

Issue: 2016, Volume 67, Issue 9

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