RADU SEBASTIAN GAVRIL, FLORIN MITU, MARIA MAGDALENA LEON, LAURA MIHALACHE, LIDIA IULIANA ARHIRE, CRISTINA GROSU, ANDREEA GHERASIM, OTILIA NITA, IRINA OANA UNGUREANU, ANDREI CATALIN OPRESCU, MARIANA GRAUR<br>Biomarkers of Inflammation in Patients with Type 2 Diabets Mellitus and Hepatic Steatosis

RADU SEBASTIAN GAVRIL, FLORIN MITU, MARIA MAGDALENA LEON, LAURA MIHALACHE, LIDIA IULIANA ARHIRE, CRISTINA GROSU, ANDREEA GHERASIM, OTILIA NITA, IRINA OANA UNGUREANU, ANDREI CATALIN OPRESCU, MARIANA GRAUR
Biomarkers of Inflammation in Patients with Type 2 Diabets Mellitus and Hepatic Steatosis

Abstract:

Non-alcoholic fatty liver disease (NAFLD) and diabetes are associations that commonly coexist and act synergistically in terms of worsening the liver disease or increasing the cardiovascular risk. Risk factors or associations thereof are looked for to reduce the cardiometabolic modifiable risk. Our study tracks the correlations between different biomarkers, especially the inflammatory ones, with a degree of fatty load in the liver, and thus with cardiovascular risk in diabetic patients. We included 92 subjects with type 2 diabetes (DM 2), with an average age of 60.38 ± 10.37 years, which were investigated by evaluating the lipid profile, inflammatory markers (CRP, fibrinogen), liver function and as ultrasound investigations we used: abdominal ultrasound with measurement of the degree of fatty liver load and carotid Doppler ultrasound, with the measurement of the carotid intima-media thickness (CIMT). Calculation of the correlation coefficients between the degree of liver steatosis and the parameters included in the study showed direct significant correlation between the degree of liver steatosis and CRP (r=0.3673, p=0.001), triglycerides (r=0.3716, p=0.001), ALT (r=0.3463, p=0.002) and AST (r=0.2432, p[0.0001) and a significant inverse correlation of HDL cholesterol (r=-0.5654, p=0.001). Also, we found a significant direct correlation of the triglycerides with CIMT (r=0.4225, p=0.001). Calculation of the correlation coefficient between CIMT and the degree of hepatic steatosis showed that CIMT directly correlates significantly with the degree of hepatic steatosis (r=0.2979, p[0.004). Thus, the usual biochemical parameters and the current simple ultrasonographic methods can assess the cardiovascular risk among people with type 2 diabetes and NAFLD. Keywords: NAFLD, diabetes, cardiovascular risk

Issue: 2016, Volume 67, Issue 9

Pages:

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)