Lacramioara PAVAL, Daniel PAVAL, Cristian Dinu POPESCU<br>Procognitive Effects of Immunomodulatory, Anticholinergic and Glutamatergic Medication in Multiple Sclerosis

Lacramioara PAVAL, Daniel PAVAL, Cristian Dinu POPESCU
Procognitive Effects of Immunomodulatory, Anticholinergic and Glutamatergic Medication in Multiple Sclerosis

Abstract:

Multiple sclerosis is the most common neurological disorder present in young population, with neurological and psychiatric disabilities. Cognitive dysfunction can occur with the onset of multiple sclerosis. Therefore, these disorders are difficult to detect early, especially when neurological disability therapy outweigh the mental state. Various pharmacological agents have been studied in order to control the cognitive impairment in multiple sclerosis. Chemical substances with immunomodulatory effect such as interferon-beta and glatiramer acetate are the first indicated in therapy. Their purpose is to reduce organic brain damage by modulating the immune response. Specific pharmacological agents with procognitive action, used in dementia treatment, correct the neuro-bio-chemical deficit that is the consequence of neuronal dysfunction and degradation that appears in multiple sclerosis evolution. Procognitive effect of these medicines stems from the anticholinergic and glutamatergic action which increases levels of acetylcholine in the brain and moderates glutamate activity reducing oxidative stress. This paper presents an analysis of studies that highlight the procognitive effects of immunomodulatory, anticholinergic and glutamatergic pharmacological agents in multiple sclerosis. Keywords: interferon-beta, glatiramer acetate, acetylcholine, procognitive effect, multiple sclerosis

Issue: 2016, Volume 67, Issue 9

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