CAMELIA VIDITA GURBAN,  OANA SUCIU, LAVINIA VLAIA, LAURA SMARANDA GOTIA, MARIOARA CORNIANU, CSILLA ZAMBORI, MARILENA MOTOC, VICENTIU VLAIA, IULIAN VELEA, MARIUS PRICOP<br>Inflammatory Markers from Crevicular Fluid in Periodontal Disease

CAMELIA VIDITA GURBAN, OANA SUCIU, LAVINIA VLAIA, LAURA SMARANDA GOTIA, MARIOARA CORNIANU, CSILLA ZAMBORI, MARILENA MOTOC, VICENTIU VLAIA, IULIAN VELEA, MARIUS PRICOP
Inflammatory Markers from Crevicular Fluid in Periodontal Disease

Abstract:

In this study there were analysed the local pro-inflammatory, anti-inflammatory and immunomodulating cytokines in the gingival crevicular fluid (GCF) in periodontal diseases (PD). It has been used the ELISA method for the determination of the immune-inflammatory markers of periodontal disease in GCF (on 117 patients). A local increase of pro-inflammatory (IL-1a, IL-1ab, IL-6, TNF-a) and immunomodulating (IFN-g) cytokines in GCF has been observed in patients with different stages of periodontitis and gingivitis (p[0.0001, respectively p[0.001), compared to healthy subjects. The anti-inflammatory cytokines (IL-4) were significantly decreased in all periodontal diseases (p[0.0001, respectively p[0.0004), vs. control group. The IL-1a and IL-1b concentrations were significantly increased in aggressive periodontitis, in comparison with gingivitis. TNF-a levels showed the same ascendant evolution in quantity in patients with gingivitis and aggressive periodontitis. IL-6 and IFN-ă had an increasing evolution as the disease progressed. Our study demonstrates the increased production of IL-1a, IL-1b, IL-6, TNF-a, IFN-g and decreased secretions of IL-4 in GCF in patients with periodontitis and gingivitis, as an expression of the inflammatory response in periodontal diseases. The imbalance favours the progressive inflammatory destruction in periodontal diseases. Keywords: pro-inflammatory, anti-inflammatory and immunomodulating cytokines, periodontitis, gingivitis

Issue: 2016, Volume 67, Issue 10

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