OANA VIOLA BADULESCU, MARIA MAGDALENA LEON, MADALINA MOCANU<br>Using Iron Chelators - deferasirox in the Treatment of Hypersiderosis

OANA VIOLA BADULESCU, MARIA MAGDALENA LEON, MADALINA MOCANU
Using Iron Chelators - deferasirox in the Treatment of Hypersiderosis

Abstract:

Hemosiderosis is a condition characterized by a pathological increase of iron levels in the body. One of the main etiologies of hemosiderosis is represented by massive transfusions of packed red blood cells, as it happens in major beta-thalassemia or in myelodysplastic syndromes, haematological disorders evolving with low values of haemoglobin which require transfusion frequently. Hypersideremia therapy consists of the administration of iron chelators. Deferasirox is a next generation iron chelator, which is administered to multiple transfused patients. It is used to prevent iron storage in deposits by increasing its excretion rate.The purpose of this paper is to highlight the role of the treatment with iron chelators, respectively Deferasirox in preventing the onset of hemosiderosis and its complications. We also intend to analyze aspects of the chemical and pharmacological profile of Deferasirox. We present the case of a 27 year-old man diagnosed with myelodysplastic syndrome of the refractory anemia type, in which increased transfusion treatment imposed by the severely low hemoglobin values, led to the risk of secondary hemosiderosis installation. We intend to emphasize the beneficial effect of iron chelators therapy, which prevents the installation of hypersideremia complications, reduces the transfusion requirements and improves patient’s quality of life. Keywords: iron, toxicity, deferasirox, hypersideremia

Issue: 2016, Volume 67, Issue 10

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