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Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
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Revista de Chimie (Rev. Chim.), Year 2016, Volume 67, Issue 10,





MIRELA AHMADI, BOGDAN DELEANU, MIHAELA OSTAN, ADRIAN STANCU, DOREL DRONCA, MIHAELA SCURTU, IULIANA CRETESCU
In vivo Experiments on Zinc Toxicity

Abstract:

Even zinc is essential mineral for living organisms, in some cases can become toxic. The aim of our research was to perform in vivo study on Wistar rats, administrating (gavage) two different high doses of ZnCl2 solutions, for a short time. Finally, we sampled different tissues (longissimus dorsi muscle, and also kidney, liver and brain) for determination of Zn concentration, by atomic absorption spectroscopy method. The results showed increased Zn concentration after Zn overdoses administration, with two exceptions: the kidney and the brain. Also, liver concentration of zinc was higher after overdosed ZnCl2 administration compared to control group (which got gavage administration of plain water). This demonstrate that Zn overdoses (short term administration), decreases Zn concentration in kidney and brain, and increased concentration in liver and longissimus dorsi in case of Wistar rats experimental animals. Keywords: longgisimus dorsi, kidney, liver, brain, Wistar rats, zinc


Issue: 2016, Volume 67, Issue 10
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