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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2016, Volume 67, Issue 10,





FELICIA DRAGAN, IRINA KACSO, FLAVIA MARTIN,GHEORGHE BORODI, IOAN BRATU, MARCEL COSTULEANU, IOAN GABRIEL SANDU, VLADIMIR POROCH
Solid State Interactions Between Ketoprofen and Excipients in Solid Dosage Forms

Abstract:

This study assesses the solid-solid interactions between the commercial form of Ketoprofen (KET), a non-steroidal anti-inflammatory drug of the propionic acid class, and several widely used pharmaceutical excipients. The work was carried out on drug-excipient mixtures, in 1:1 (w:w) ratio, blended in an agate mortar at room temperature. The compatibility/incompatibility of KET with the proposed excipients was highlighted by the most commonly used analytic methods: differential scanning calorimetry (DSC), Fourier transformed infrared spectroscopy (FT-IR) and powder X-ray diffraction (PXRD). The interactions between KET and three of the excipients, namely Macrogol 6000, magnesium stearate dehydrate and lactose monohydrate were evidenced by DSC and further confirmed by FT-IR and PXRD analysis. Keywords: Ketoprofen, excipients, thermal analysis, FT-IR spectroscopy, X-ray diffraction


Issue: 2016, Volume 67, Issue 10
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