ANCA  DANIELA  FARCAS, MIRELA ANCA STOIA, FLORIN PETRU ANTON, DIANA MOCAN HOGNOGI, RALUCA DIANA IANOS, SILVANA ELENA SUSCA HOJDA, IULIA LAURA GAVRILA, DELIA LUTAC, IRINA IOANA BURIAN, LUMINITA ANIMARIE VIDA SIMITI<br>The Lymphocyte Count and Neutrophil/lymphocyte Ratio are Independent Predictors for Adverse Cardiac Events in Ischemic <br>Heart Failure but not with Non-ischemic Heart Failure

ANCA DANIELA FARCAS, MIRELA ANCA STOIA, FLORIN PETRU ANTON, DIANA MOCAN HOGNOGI, RALUCA DIANA IANOS, SILVANA ELENA SUSCA HOJDA, IULIA LAURA GAVRILA, DELIA LUTAC, IRINA IOANA BURIAN, LUMINITA ANIMARIE VIDA SIMITI
The Lymphocyte Count and Neutrophil/lymphocyte Ratio are Independent Predictors for Adverse Cardiac Events in Ischemic
Heart Failure but not with Non-ischemic Heart Failure

Abstract:

The predictive value of some biomarkers in heart failure is not yet established. A high value of white blood cell (WBC) count and neutrophil/lymphocyte ratio (NLR) was found to be a marker of higher long term cardiovascular mortality in patients with ischemic heart disease. Recent data suggests that some specific types of leucocytes have different predictive values for the cardiovascular risk. This value is improved by using NLR. The purpose of the study was to evaluate the predictive values of WBC count, NLR, WBC differential formula (WBC-DF) for cardiovascular events in patients with non-ischemic heart failure (NIHF) as compared with ischemic heart failure (IHF). Our study included 256 patients with HF (147 with IHF and 109 with NIHF), NYHA class II-IV. They signed informed consent and underwent clinical and laboratory assessment: lipid profile, NT-proBNP, CRP, WBC, NLR and WBC-DF. The patients were followed up for one year. In patients with IHF, significantly higher levels of NT-proBNP (p[0.001), CRP (p[0.005), WBC (p[0.005), lymphocytes (p[0.05) and NRL values (1.27 (1.2-1.36) vs 0.99 (0.4 - 1.15), p[0.02) were found as compared with NIHF. A significant difference between NLR values was found only in patients in NYHA class II vs III. A positive correlation between NRL and NT-proBNP level was found (p[0.05). The lymphocyte count, NLR and NYHA class (p[0.001) represent independent predictors for the rehospitalization and cardiac events in HF patients. Our study has shown that for patients in the same NYHA class, the lymphocyte count and NLR are independent predictors for adverse cardiac events only in IHF. Keywords: lymphocyte count, neutrophil/lymphocyte ratio, biomarkers, predictive factors, ischemic heart failure, non-ischemic heart failure

Issue: 2016, Volume 67, Issue 10

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