GRIGORE TINICA, RALUCA OZANA CHISTOL, MARIA MAGDALENA LEON CONSTANTIN, ROXANA GABRIELA COBZARU, CARMEN VALERICA RIPA, CRISTINA FURNICA<br>Biomarkers for Evaluation of Postoperative Myocardial <br>Necrosis in Vascular Surgery

GRIGORE TINICA, RALUCA OZANA CHISTOL, MARIA MAGDALENA LEON CONSTANTIN, ROXANA GABRIELA COBZARU, CARMEN VALERICA RIPA, CRISTINA FURNICA
Biomarkers for Evaluation of Postoperative Myocardial
Necrosis in Vascular Surgery

Abstract:

Myocardial necrosis is one of the leading causes of postoperative adverse events in vascular surgery. Early diagnosis of mild and moderate myocardial necrosis may allow a better understanding of its pathophysiological basis as it is often associated with predisposing events and may occur in patients with no or mild coronary arteries disease. The current study aims to evaluate the role of the cardiac troponin I (cTnI) biomarker in diagnosing mild and moderate postoperative cardiac events, its prognostic value and dynamics related to patient’s evolution. The authors retrospectively analysed 102 patients undergoing open repair surgery for abdominal aortic aneurysm between January 2010 - October 2015 at the Cardiovascular Diseases Institute (Iasi, Romania). All patients were followed-up for minimum 6 months postoperatively and the status of all patients was known at the end of study. During the study period, 12 patients (11.76%) deceased, and age (OR 2.3), postoperative cTnI (OR 1.5) and haemoglobin (OR 0.7) proved to be independent mortality risk factors. In conclusion, the current study proves that cTnI has a prognostic value for short, mid and long term mortality following abdominal aorta surgery and low elevations of cTnI should be included in the definition of the postoperative cardiac morbidity. Keywords: cardiac troponin I, creatine kinase muscle-brain, biomarker, myocardial necrosis

Issue: 2016, Volume 67, Issue 11

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