OANA VIOLA BADULESCU, ROXANA HULTOANA, MADALINA MOCANU, MARIA MAGDALENA LEON CONSTANTIN, STEFAN OCTAVIAN GEORGESCU<br>The Importance of Using the Glucocorticoid 9 - fluoro - 16 Methylprednisolone Therapy Before Splenectomy in Patients with Idiopathic Thrombocytopenic Purpura

OANA VIOLA BADULESCU, ROXANA HULTOANA, MADALINA MOCANU, MARIA MAGDALENA LEON CONSTANTIN, STEFAN OCTAVIAN GEORGESCU
The Importance of Using the Glucocorticoid 9 - fluoro - 16 Methylprednisolone Therapy Before Splenectomy in Patients with Idiopathic Thrombocytopenic Purpura

Abstract:

Idiopathic thrombocytopenic purpura is an autoimmune haematological condition that involves low platelet count in the peripheral blood of a lower amount of 100,000 items / mm3. Thrombocytopenia is due to either a central cause, such as inhibition of platelets synthesis in the bone marrow or an accelerated hiperdistruction in the periphery. Intensified capture and destruction of platelets is most often induced by splenomegaly and hypersplenism. In patients with low platelets accompanied by splenomegaly refractory to drug, the only opimal therapy is the therapeutic splenectomy. Splenectomy is a surgical therapeutic manever indicated in multiple diseases, especially in the hematological field, practiced in order to increase the lifespan of platelets and decrease transfusion requirements. Although in idiopathic thrombocytopenic purpura, splenectomy is not curative, it leads to improvement of symptoms and an increase in platelets. Also, it is noted in patients with idiopathic thrombocytopenic purpura splenectomised no further need of immunosuppressive treatment and improved quality of life. Making splenectomy in the context of a low platelet count accurately involves establishing safety measures be put in place to avoid accidents with serious bleeding. The main measure is to balance patient by administering drug therapy leading to increased levels of platelets prior to surgery. The treatment methods are used corticosteroid therapy, and platelet concentrate. Product with potent glucocorticoid synthesis and conferring a remarkable increase in the number of platelets is dexamethasone (9-fluoro-16-methylprednisolone). This paper aims to highlight the importance of using therapy with 9-fluoro-16-methylprednisolone as a prophylactic measure against intraoperative bleeding incidents in patients with idiopathic thrombocytopenic purpura who will be practicing splenectomy. Keywords: 9 - fluoro - 16 methylprednisolone, splenectomy, idiopathic thrombocytopenic purpura, hemorrhagic syndrome

Issue: 2016, Volume 67, Issue 11

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