ANCA PANTALON, DORIN CHISELITA, DANIELA CONSTANTINESCU, CAMELIA BOGDANICI, CRENGUTA FERARU<br>Comparison of Inflammatory Status and Biochemical Changes in Patients with Open Angle Glaucoma and Type II Diabetes

ANCA PANTALON, DORIN CHISELITA, DANIELA CONSTANTINESCU, CAMELIA BOGDANICI, CRENGUTA FERARU
Comparison of Inflammatory Status and Biochemical Changes in Patients with Open Angle Glaucoma and Type II Diabetes

Abstract:

Comparison of inflammatory status and biochemical changes in patients with open angle glaucoma and type II diabetes represents a novel approach for a better understanding of possible correlations between these pathologies. The aim of this study was to perform such analysis and report evidences of common pathogenic pathways. We elaborated a protocol for a prospective cohort study in a tertiary ophthalmology center; patients with open angle glaucoma and diabetes were selected between October 2012-October 2014. Study included two research groups: 74 open angle glaucoma eyes (control group) and 44 eyes with open angle glaucoma + diabetes (study group). All patients were clinically evaluated by experienced ophthalmologists, and biochemical profile was assessed individually. The two study groups proved similar on age and sex ratio distribution; visual field parameters were significantly different between groups. We detected significant differences in biochemical profile between groups, that matched the difference in the functional status in glaucoma vs diabetic glaucoma patients. Therefore our study proves by comparison that changes in the biochemical profile are visible in glaucoma versus glaucoma and diabetes patients. As expected the biochemical parameters are influenced by diabetes in terms of increased inflammation, immune response and active phase reactants, but also important changes were detected in glaucoma patients. Based on this result authors could explain common pathogenic theories in glaucoma and diabetes using simple and cost effective biochemical methods. Key words: open angle glaucoma, diabetes, biochemical profile

Issue: 2016, Volume 67, Issue 11

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