ADINA STOIAN, KAMEL EARAR, CRISTIAN BUDACU, SEPTIMIU VOIDAZAN, ANDREI CRAUCIUC, MIRCEA STOIAN, CRISTINA IOANA BICA, CLAUDIA BANESCU<br>No Association Between Antioxidant Enzyme Gene Polymorphism 			and Albuminuria in Type 2 Diabetes Mellitus Cases

ADINA STOIAN, KAMEL EARAR, CRISTIAN BUDACU, SEPTIMIU VOIDAZAN, ANDREI CRAUCIUC, MIRCEA STOIAN, CRISTINA IOANA BICA, CLAUDIA BANESCU
No Association Between Antioxidant Enzyme Gene Polymorphism and Albuminuria in Type 2 Diabetes Mellitus Cases

Abstract:

Diabetic nephropathy is a frequent microvascular complication of type 2 diabetes mellitus (T2DM) and it represents one of the main causes of end stage renal disease its initial manifestation consisting in increased urinary excretion of albumin (albuminuria) which can slowly progress to overt albuminuria and renal failure. Susceptibility to develop diabetic nephropathy is modulated by genetic factors and oxidative stress play an important role. We investigated the relation between polymorphisms in genes related to oxidative stress and the presence of albuminuria in T2DM patients. Blood samples for biochemical and genetic analysis were collected from 98 patients with T2DM. Albuminuria was analyzed from a 12 h overnight urine sample and was graded after the value of albumin to creatinine ratio (ACR) as normoalbuminuria (0-30 mg/g) and albuminuria (ACR ] 30 mg/g) and patients with persistent albuminuria were included in the group with albuminuria.In our study we found a statistically significant association between peripheral neuropathy and the presence of albuminuria (p=0.005) and statistically significant association between low HDL-cholesterol level and the presence of albuminuria (p=0.02). GSTM1, GSTT1, GSTP1 Ile105Val, GPX1 Pro198Leu, CAT C262T polymorphism was not associated with the presence of albuminuria in T2DM patients. The present study suggests that GSTM1, GSTT1 and GSTP1 Ile105Val, GPX1 Pro198Leu and CAT C262T gene polymorphisms are not associated with the susceptibility of the diabetic patients to develop albuminuria. Key words: oxidative stress, albuminuria, diabetes mellitus, CAT C262T, GPX1

Issue: 2016, Volume 67, Issue 11

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