IZABELLA PETRE, ELENA BERNAD, MARIUS CRAINA, COSMIN CITU, SORIN BOLINTINEANU, ELENA POP, DANA STOIAN, SIMONA SIPOS, DIANA LUNGEANU, CRISTIAN FURAU, GHEORGHE FURAU, STELIAN PANTEA, IOANA IONITA<br>Determining Markers PlGF, sFlt1 and the Ratio <br>sFlt1/PlGF - Prognostic Tool in Patients with Preeclampsia

IZABELLA PETRE, ELENA BERNAD, MARIUS CRAINA, COSMIN CITU, SORIN BOLINTINEANU, ELENA POP, DANA STOIAN, SIMONA SIPOS, DIANA LUNGEANU, CRISTIAN FURAU, GHEORGHE FURAU, STELIAN PANTEA, IOANA IONITA
Determining Markers PlGF, sFlt1 and the Ratio
sFlt1/PlGF - Prognostic Tool in Patients with Preeclampsia

Abstract:

Preeclampsia represents a pregnancy complication characterized by high blood pressure and proteinuria, after the 20th week of gestation. It appears in 3-5% of pregnant women, having a substantial maternal, foetal and neo-natal mortality and morbidity rate. In a normal pregnancy: the PIGF (package factor) serum level increases in the first two trimesters of pregnancy and decreases as the pregnancy comes to term; the serum level of sFlt-1 remains stable in the first two trimesters of pregnancy, and then increases as the pregnancy comes to term. In the cases of women who develop preeclampsia, the level of sFlt-1 is higher and that of PIGF is lower, than in normal pregnancies. The ration of sFlt-1/PIGF is a better indicator of preeclampsia than any other of the two individually evaluated factors. The results of our study come to confirm the importance of determining these markers for the diagnosis and monitoring of pregnant women and at the same time to highlight the fact that the ratio of sFlt- 1/PlGF represents a good predictor of preeclampsia. Keywords: gestational age, PlGF, preeclamsia, pregnancy, sFlt1

Issue: 2016, Volume 67, Issue 11

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