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REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2016, Volume 67, Issue 12,





Pavle Z. Maskovic, Mira Ac, Milan Pavlovic, Mladen R. Vujosevic, Jelena V. Blagojevic,Milena Djuric, Slavica Veskovic Moracanin, Dragutin A. Djukic
A Study on the Ethanolic Extract of Onosma aucheriana
Biological and toxicological evaluation

Abstract:

This research studies the antioxidant activity and efficacy of the ethanolic extract of the plant species Onosma aucheriana DC. This plant growing wild in Serbia, in inhibiting the development of selected fungi and bacteria. The most sensitive to the ethanolic extracts were bacteria B. subtilis and S. aureus (MIC = 15.62 mg/mL), while the fungi, A. niger (MIC = 15.62 mg/mL) showed the highest susceptibility. Total phenolic, flavonoid, condensed tannin and gallotannin contents were 90.26 mg GA/g, 35.24 mg RU/g, 74.65 mg GA/g and 31.74 mg GA/g, respectively. Phenolic compounds are found as dominant in the extract of rosmarinic acid. Total antioxidant capacity was 78.45 mg AA/g. IC50 values were determined for each measurement: 21.45 mg/mL for DPPH free radical scavenging activity, 36.46 mg/mL for inhibitory activity against lipid peroxidation, 99.11 mg/mL for hydroxyl radical scavenging activity and 45.91 mg/mL for chelating ability. A potent inhibitor of cell growth to all three cell lines (Hep2c, RD, L2OB) is the ethanol extract of plant species O. aucheriana . Results of Allium anaphase-telophase genotoxicity assay revealed that the ethanolic extract of O. aucheriana at concentrations of 62.5 mg/mL does not produce toxic or genotoxic effects. Keywords: antimicrobial activity, antioxidant activity, genotoxic examination, cytotoxic activity, Onosma aucheriana DC., HPLC analysis, phenolic compounds

Issue: 2016, Volume 67, Issue 12
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