Bogdan Horatiu Serb, Alina Ormenisan, Ancuta Pleseru, Vlad Preluca, Mihaela Cernusca Mitariu, Corina Roman Filip, Horia Mihail Barbu, Sebastian Cernusca Mitariu
Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala
Abstract:
The glycinergic neurotransmission system is a potential pharmacological target for pain and muscle spasm relief therapy. Planarians are attractive model organisms for neuropharmacological research, due to their simplicity and neurotransmitters shared with mammals. In this study, planarians were exposed to glycine, caffeine, midazolam and ondansetron separately and to successive associations of glycine/caffeine, glycine/midazolam and glycine/ondansetron. Effects on motility were examined by a grid crossing assay. Results showed a dose-dependent reduction of motility by glycine, partially reversed by caffeine and midazolam, but not by ondansetron. Midazolam caused an intense decrease of motility, but not significantly lower than glycine. Ondansetron-treated planarians showed decrease motility compared with controls, but not with glycine or midazolam. These results are consistent with data obtained from higher organisms, showing that planarians can be used as model organisms for glycinergic pharmacological research.
Cite this article as: SERB, B.H., ORMENISAN, A., PLESERU, A., PRELUCA, V., MITARIU, M.C., FILIP, C.R., BARBU, H.M., MITARIU, S.C., Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala, Rev. Chim., 68(1), 2017, 172-174.
Vancouver Serb BH, Ormenisan A, Pleseru A, Preluca V, Mitariu MC, Filip CR, Barbu HM, Mitariu SC. Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala. Rev. Chim.[internet]. 2017 Jan;68(1):172-174. Available from: https://doi.org/10.37358/RC.17.1.5413
APA 6th edition Serb, B.H., Ormenisan, A., Pleseru, A., Preluca, V., Mitariu, M.C., Filip, C.R., Barbu, H.M. & Mitariu, S.C. (2017). Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala. Revista de Chimie, 68(1), 172-174. https://doi.org/10.37358/RC.17.1.5413
Harvard Serb, B.H., Ormenisan, A., Pleseru, A., Preluca, V., Mitariu, M.C., Filip, C.R., Barbu, H.M., Mitariu, S.C. (2017). 'Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala', Revista de Chimie, 68(1), pp. 172-174. https://doi.org/10.37358/RC.17.1.5413
IEEE B.H. Serb, A. Ormenisan, A. Pleseru, V. Preluca, M.C. Mitariu, C.R. Filip, H.M. Barbu, S.C. Mitariu, "Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala". Revista de Chimie, vol. 68, no. 1, pp. 172-174, 2017. [online]. https://doi.org/10.37358/RC.17.1.5413
Text Bogdan Horatiu Serb, Alina Ormenisan, Ancuta Pleseru, Vlad Preluca, Mihaela Cernusca Mitariu, Corina Roman Filip, Horia Mihail Barbu, Sebastian Cernusca Mitariu, Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala, Revista de Chimie, Volume 68, Issue 1, 2017, Pages 172-174, ISSN 2668-8212, https://doi.org/10.37358/RC.17.1.5413. (https://revistadechimie.ro/Articles.asp?ID=5413) Keywords: glycine; motility; planarians
RIS TY - JOUR T1 - Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala A1 - Serb, Bogdan Horatiu A2 - Ormenisan, Alina A3 - Pleseru, Ancuta A4 - Preluca, Vlad A5 - Mitariu, Mihaela Cernusca A6 - Filip, Corina Roman A7 - Barbu, Horia Mihail A8 - Mitariu, Sebastian Cernusca JF - Revista de Chimie JO - Rev. Chim. PB - Revista de Chimie SRL SN - 2668-8212 Y1 - 2017 VL - 68 IS - 1 SP - 172 EP - 174 UR - https://doi.org/10.37358/RC.17.1.5413 KW - glycine KW - motility KW - planarians ER -
BibTex @article{RevCh2017P172, author = {Serb Bogdan Horatiu and Ormenisan Alina and Pleseru Ancuta and Preluca Vlad and Mitariu Mihaela Cernusca and Filip Corina Roman and Barbu Horia Mihail and Mitariu Sebastian Cernusca}, title = {Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala}, journal = {Revista de Chimie}, volume = {68}, number = {1}, pages = {172-174}, year = {2017}, issn = {2668-8212}, doi = {https://doi.org/10.37358/RC.17.1.5413}, url = {https://revistadechimie.ro/Articles.asp?ID=5413} }
