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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2017, Volume 68, Issue 1, 172-174

https://doi.org/10.37358/RC.17.1.5413

Bogdan Horatiu Serb, Alina Ormenisan, Ancuta Pleseru, Vlad Preluca, Mihaela Cernusca Mitariu, Corina Roman Filip, Horia Mihail Barbu, Sebastian Cernusca Mitariu

Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala

Abstract:

The glycinergic neurotransmission system is a potential pharmacological target for pain and muscle spasm relief therapy. Planarians are attractive model organisms for neuropharmacological research, due to their simplicity and neurotransmitters shared with mammals. In this study, planarians were exposed to glycine, caffeine, midazolam and ondansetron separately and to successive associations of glycine/caffeine, glycine/midazolam and glycine/ondansetron. Effects on motility were examined by a grid crossing assay. Results showed a dose-dependent reduction of motility by glycine, partially reversed by caffeine and midazolam, but not by ondansetron. Midazolam caused an intense decrease of motility, but not significantly lower than glycine. Ondansetron-treated planarians showed decrease motility compared with controls, but not with glycine or midazolam. These results are consistent with data obtained from higher organisms, showing that planarians can be used as model organisms for glycinergic pharmacological research.
Keywords:
glycine; motility; planarians

Issue: 2017, Volume 68, Issue 1
Pages: 172-174
Publication date: 2017/2/15
https://doi.org/10.37358/RC.17.1.5413
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
SERB, B.H., ORMENISAN, A., PLESERU, A., PRELUCA, V., MITARIU, M.C., FILIP, C.R., BARBU, H.M., MITARIU, S.C., Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala, Rev. Chim., 68(1), 2017, 172-174.

Vancouver
Serb BH, Ormenisan A, Pleseru A, Preluca V, Mitariu MC, Filip CR, Barbu HM, Mitariu SC. Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala. Rev. Chim.[internet]. 2017 Jan;68(1):172-174. Available from: https://doi.org/10.37358/RC.17.1.5413


APA 6th edition
Serb, B.H., Ormenisan, A., Pleseru, A., Preluca, V., Mitariu, M.C., Filip, C.R., Barbu, H.M. & Mitariu, S.C. (2017). Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala. Revista de Chimie, 68(1), 172-174. https://doi.org/10.37358/RC.17.1.5413


Harvard
Serb, B.H., Ormenisan, A., Pleseru, A., Preluca, V., Mitariu, M.C., Filip, C.R., Barbu, H.M., Mitariu, S.C. (2017). 'Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala', Revista de Chimie, 68(1), pp. 172-174. https://doi.org/10.37358/RC.17.1.5413


IEEE
B.H. Serb, A. Ormenisan, A. Pleseru, V. Preluca, M.C. Mitariu, C.R. Filip, H.M. Barbu, S.C. Mitariu, "Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala". Revista de Chimie, vol. 68, no. 1, pp. 172-174, 2017. [online]. https://doi.org/10.37358/RC.17.1.5413


Text
Bogdan Horatiu Serb, Alina Ormenisan, Ancuta Pleseru, Vlad Preluca, Mihaela Cernusca Mitariu, Corina Roman Filip, Horia Mihail Barbu, Sebastian Cernusca Mitariu,
Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala,
Revista de Chimie,
Volume 68, Issue 1,
2017,
Pages 172-174,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.1.5413.
(https://revistadechimie.ro/Articles.asp?ID=5413)
Keywords: glycine; motility; planarians


RIS
TY - JOUR
T1 - Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala
A1 - Serb, Bogdan Horatiu
A2 - Ormenisan, Alina
A3 - Pleseru, Ancuta
A4 - Preluca, Vlad
A5 - Mitariu, Mihaela Cernusca
A6 - Filip, Corina Roman
A7 - Barbu, Horia Mihail
A8 - Mitariu, Sebastian Cernusca
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 1
SP - 172
EP - 174
UR - https://doi.org/10.37358/RC.17.1.5413
KW - glycine
KW - motility
KW - planarians
ER -


BibTex
@article{RevCh2017P172,
author = {Serb Bogdan Horatiu and Ormenisan Alina and Pleseru Ancuta and Preluca Vlad and Mitariu Mihaela Cernusca and Filip Corina Roman and Barbu Horia Mihail and Mitariu Sebastian Cernusca},
title = {Pharmacodynamic Modulation of Motility by Glycine Administration in Dugesia Dorotocephala},
journal = {Revista de Chimie},
volume = {68},
number = {1},
pages = {172-174},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.1.5413},
url = {https://revistadechimie.ro/Articles.asp?ID=5413}
}
 
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