In vivo Experimental Study on the Influence of Sodium Fluoride and Amoxicillin/Clavulanic Acid on the Minerals Composition of Dental Enamel

Mihalas, Eugeniu; Ogodescu, Alexandru; Balan, Adriana; Aminov, Liana; Decolli, Yllka; Gavrila, Laura; Savin, Carmen

Eugeniu Mihalas, Alexandru Ogodescu, Adriana Balan, Liana Aminov, Yllka Decolli, Laura Gavrila, Carmen Savin

In vivo Experimental Study on the Influence of Sodium Fluoride and Amoxicillin/Clavulanic Acid on the Minerals Composition of Dental Enamel

Abstract:

The aim of this study was to assess the morphological and chemical composition changes induced by the chronic intake of sodium fluoride (NaF) and Amoxicillin in mice enamel. 35 C57BL/6 adult male mice, were randomly divided into a control and 4 treatment groups (n = 7). After acclimatization, the experimental groups were simultaneously treated with 25 ppm (group 2 and 3) and 50ppm (group 4 and 5) of NaF, and 50mg/kg BW (group 2 and 4) and 100 mg/kg BW (group 3 and 5) of Amoxicillin as Amoxicillin/clavulanic acid (AMC). NaF was supplied through drinking water without restricting access, and AMC administered through subcutaneous injection, once per day, for 60 days. After harvesting, lower incisors’ enamel was subjected to a scanning electron microscope (SEM) and to an energy dispersive X-ray analysis (EDX). In the treatment groups, SEM and EDX analysis in treatment groups showed an increasing trend of weight percentage (wt%) for C, N, O, F, Na and C/O, F/Fe ratio, and also a decreasing trend of wt% for P, Cl, Ca, Fe and Ca/P ratio. Morphological changes ranged from fissures and short grooves with pits-like appearance, in group 2 sometimes associated with limited demineralized areas looking like irregular scratches, up to demineralized areas extended in the outer enamel, which in group 5 gives the enamel the corroded look. The severity of the morphological changes in the mice enamel varied with the supplied dose of NaF and AMC, and had a uniform pattern in each experimental group. SEM analysis revealed a hypoplasia on the outer enamel and EDX analysis showed a hypomineralisation at the level of the outer enamel.

Keywords:
teeth; fluorosis; hypomineralization; SEM; amoxicillin; sodium fluoride

Issue: 2017, Volume 68, Issue 2

Pages: 269-272

Publication date: 2017/3/15

https://doi.org/10.37358/RC.17.2.5434

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MIHALAS, E., OGODESCU, A., BALAN, A., AMINOV, L., DECOLLI, Y., GAVRILA, L., SAVIN, C., In vivo Experimental Study on the Influence of Sodium Fluoride and Amoxicillin/Clavulanic Acid on the Minerals Composition of Dental Enamel, Rev. Chim., 68(2), 2017, 269-272.

Vancouver
Mihalas E, Ogodescu A, Balan A, Aminov L, Decolli Y, Gavrila L, Savin C. In vivo Experimental Study on the Influence of Sodium Fluoride and Amoxicillin/Clavulanic Acid on the Minerals Composition of Dental Enamel. Rev. Chim.[internet]. 2017 Feb;68(2):269-272. Available from: https://doi.org/10.37358/RC.17.2.5434

APA 6th edition
Mihalas, E., Ogodescu, A., Balan, A., Aminov, L., Decolli, Y., Gavrila, L. & Savin, C. (2017). In vivo Experimental Study on the Influence of Sodium Fluoride and Amoxicillin/Clavulanic Acid on the Minerals Composition of Dental Enamel. Revista de Chimie, 68(2), 269-272. https://doi.org/10.37358/RC.17.2.5434

Harvard
Mihalas, E., Ogodescu, A., Balan, A., Aminov, L., Decolli, Y., Gavrila, L., Savin, C. (2017). 'In vivo Experimental Study on the Influence of Sodium Fluoride and Amoxicillin/Clavulanic Acid on the Minerals Composition of Dental Enamel', Revista de Chimie, 68(2), pp. 269-272. https://doi.org/10.37358/RC.17.2.5434

IEEE
E. Mihalas, A. Ogodescu, A. Balan, L. Aminov, Y. Decolli, L. Gavrila, C. Savin, "In vivo Experimental Study on the Influence of Sodium Fluoride and Amoxicillin/Clavulanic Acid on the Minerals Composition of Dental Enamel". Revista de Chimie, vol. 68, no. 2, pp. 269-272, 2017. [online]. https://doi.org/10.37358/RC.17.2.5434

Text
Eugeniu Mihalas, Alexandru Ogodescu, Adriana Balan, Liana Aminov, Yllka Decolli, Laura Gavrila, Carmen Savin,
In vivo Experimental Study on the Influence of Sodium Fluoride and Amoxicillin/Clavulanic Acid on the Minerals Composition of Dental Enamel,
Revista de Chimie,
Volume 68, Issue 2,
2017,
Pages 269-272,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.2.5434.
(https://revistadechimie.ro/Articles.asp?ID=5434)
Keywords: teeth; fluorosis; hypomineralization; SEM; amoxicillin; sodium fluoride

RIS
TY - JOUR
T1 - In vivo Experimental Study on the Influence of Sodium Fluoride and Amoxicillin/Clavulanic Acid on the Minerals Composition of Dental Enamel
A1 - Mihalas, Eugeniu
A2 - Ogodescu, Alexandru
A3 - Balan, Adriana
A4 - Aminov, Liana
A5 - Decolli, Yllka
A6 - Gavrila, Laura
A7 - Savin, Carmen
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 2
SP - 269
EP - 272
UR - https://doi.org/10.37358/RC.17.2.5434
KW - teeth
KW - fluorosis
KW - hypomineralization
KW - SEM
KW - amoxicillin
KW - sodium fluoride
ER -

BibTex
@article{RevCh2017P269,
author = {Mihalas Eugeniu and Ogodescu Alexandru and Balan Adriana and Aminov Liana and Decolli Yllka and Gavrila Laura and Savin Carmen},
title = {In vivo Experimental Study on the Influence of Sodium Fluoride and Amoxicillin/Clavulanic Acid on the Minerals Composition of Dental Enamel},
journal = {Revista de Chimie},
volume = {68},
number = {2},
pages = {269-272},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.2.5434},
url = {https://revistadechimie.ro/Articles.asp?ID=5434}
}

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