Studies on Obtaining and Characterization a Pregabalin-cyclodextrin Complex for Taste Masking Purpose

Popa, Gratiela; Dragostin, Oana; Buzia, Olimpia Dumitriu; Tartau, Liliana Mititelu; Profire, Lenuta; Gafitanu, Carmen

Gratiela Popa, Oana Dragostin, Olimpia Dumitriu Buzia, Liliana Mititelu Tartau, Lenuta Profire, Carmen Gafitanu

Studies on Obtaining and Characterization a Pregabalin-cyclodextrin Complex for Taste Masking Purpose

Abstract:

Pregabalin is an anticonvulsant and analgesic drug that stirs more and more the interest of the researchers. Its stability, solubility and taste can be modified by obtaining complexes with cyclodextrins. For this purpose, in the present study betacyclodextrin and hydroxypropyl-betacyclodextrin were included. The obtaining of inclusion complexes was confirmed by ATR-FTIR spectroscopy and UV spectroscopy. The results demonstrated that it is possible to develop inclusion complexes of pregabalin with betacyclodextrin and hydroxypropyl-betacyclodextrin, with moderate efficiency.

Keywords:
inclusion complex; pregabalin; betacyclodextrin; hydroxypropyl-betacyclodextrin

Issue: 2017, Volume 68, Issue 2

Pages: 337-340

Publication date: 2017/3/15

https://doi.org/10.37358/RC.17.2.5448

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
POPA, G., DRAGOSTIN, O., BUZIA, O.D., TARTAU, L.M., PROFIRE, L., GAFITANU, C., Studies on Obtaining and Characterization a Pregabalin-cyclodextrin Complex for Taste Masking Purpose, Rev. Chim., 68(2), 2017, 337-340.

Vancouver
Popa G, Dragostin O, Buzia OD, Tartau LM, Profire L, Gafitanu C. Studies on Obtaining and Characterization a Pregabalin-cyclodextrin Complex for Taste Masking Purpose. Rev. Chim.[internet]. 2017 Feb;68(2):337-340. Available from: https://doi.org/10.37358/RC.17.2.5448

APA 6th edition
Popa, G., Dragostin, O., Buzia, O.D., Tartau, L.M., Profire, L. & Gafitanu, C. (2017). Studies on Obtaining and Characterization a Pregabalin-cyclodextrin Complex for Taste Masking Purpose. Revista de Chimie, 68(2), 337-340. https://doi.org/10.37358/RC.17.2.5448

Harvard
Popa, G., Dragostin, O., Buzia, O.D., Tartau, L.M., Profire, L., Gafitanu, C. (2017). 'Studies on Obtaining and Characterization a Pregabalin-cyclodextrin Complex for Taste Masking Purpose', Revista de Chimie, 68(2), pp. 337-340. https://doi.org/10.37358/RC.17.2.5448

IEEE
G. Popa, O. Dragostin, O.D. Buzia, L.M. Tartau, L. Profire, C. Gafitanu, "Studies on Obtaining and Characterization a Pregabalin-cyclodextrin Complex for Taste Masking Purpose". Revista de Chimie, vol. 68, no. 2, pp. 337-340, 2017. [online]. https://doi.org/10.37358/RC.17.2.5448

Text
Gratiela Popa, Oana Dragostin, Olimpia Dumitriu Buzia, Liliana Mititelu Tartau, Lenuta Profire, Carmen Gafitanu,
Studies on Obtaining and Characterization a Pregabalin-cyclodextrin Complex for Taste Masking Purpose,
Revista de Chimie,
Volume 68, Issue 2,
2017,
Pages 337-340,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.2.5448.
(https://revistadechimie.ro/Articles.asp?ID=5448)
Keywords: inclusion complex; pregabalin; betacyclodextrin; hydroxypropyl-betacyclodextrin

RIS
TY - JOUR
T1 - Studies on Obtaining and Characterization a Pregabalin-cyclodextrin Complex for Taste Masking Purpose
A1 - Popa, Gratiela
A2 - Dragostin, Oana
A3 - Buzia, Olimpia Dumitriu
A4 - Tartau, Liliana Mititelu
A5 - Profire, Lenuta
A6 - Gafitanu, Carmen
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 2
SP - 337
EP - 340
UR - https://doi.org/10.37358/RC.17.2.5448
KW - inclusion complex
KW - pregabalin
KW - betacyclodextrin
KW - hydroxypropyl-betacyclodextrin
ER -

BibTex
@article{RevCh2017P337,
author = {Popa Gratiela and Dragostin Oana and Buzia Olimpia Dumitriu and Tartau Liliana Mititelu and Profire Lenuta and Gafitanu Carmen},
title = {Studies on Obtaining and Characterization a Pregabalin-cyclodextrin Complex for Taste Masking Purpose},
journal = {Revista de Chimie},
volume = {68},
number = {2},
pages = {337-340},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.2.5448},
url = {https://revistadechimie.ro/Articles.asp?ID=5448}
}

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