Chemo-physical Properties and Biomedical Applications of Hyaluronic Acid in Medicine

Vasile, Danut; Iancu, Raluca; Bogdanici, Camelia; Ungureanu, Emil; Ciobotea, Dana; Ciuluvica, Radu; Iancu, George

Danut Vasile, Raluca Iancu, Camelia Bogdanici, Emil Ungureanu, Dana Ciobotea, Radu Ciuluvica, George Iancu

Chemo-physical Properties and Biomedical Applications of Hyaluronic Acid in Medicine

Abstract:

Hyaluronic acid is a mucopolysaccharide encountered in most body fluids and extracellular matrix. The aim of our review is to summarize current evidence about chemico-physical properties of hyaluronic acid, highlighting biomedical applications of hyaluronan derivatives. It is a glycosaminoglycan made of repeating disaccharide units containing a carboxylate group, four hydroxyl groups and one carboxylate group, with hydrophilic properties. Its particular structure with multiple coils forming an entangled network results in unique pseudoplastic and viscoelastic characteristics. Its viscous and elastic behavior, depending on the applied strain, makes hyaluronan widely applicable in biomedical field. The large amount of functions and applications is determined by the physico-chemical properties, which allows a polymorphism of the hyaluronic acid structures depending on the molecular weight variations, concentration and ionic status. It is currently used in ophthalmology, orthopedics and rheumatology, in plastic surgery, surgery and otolaryngology as well. Already widely used in clinical practice, hyaluronic acid proves to be often the best solution for difficult medical problems. Future developments in nanomedicine and drug delivery linked to hyaluronic acid are emerging.

Keywords:
Hyaluronic acid; Glycosaminoglycan; Viscoelastic properties

Issue: 2017, Volume 68, Issue 2

Pages: 384-386

Publication date: 2017/3/15

https://doi.org/10.37358/RC.17.2.5458

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
VASILE, D., IANCU, R., BOGDANICI, C., UNGUREANU, E., CIOBOTEA, D., CIULUVICA, R., IANCU, G., Chemo-physical Properties and Biomedical Applications of Hyaluronic Acid in Medicine, Rev. Chim., 68(2), 2017, 384-386.

Vancouver
Vasile D, Iancu R, Bogdanici C, Ungureanu E, Ciobotea D, Ciuluvica R, Iancu G. Chemo-physical Properties and Biomedical Applications of Hyaluronic Acid in Medicine. Rev. Chim.[internet]. 2017 Feb;68(2):384-386. Available from: https://doi.org/10.37358/RC.17.2.5458

APA 6th edition
Vasile, D., Iancu, R., Bogdanici, C., Ungureanu, E., Ciobotea, D., Ciuluvica, R. & Iancu, G. (2017). Chemo-physical Properties and Biomedical Applications of Hyaluronic Acid in Medicine. Revista de Chimie, 68(2), 384-386. https://doi.org/10.37358/RC.17.2.5458

Harvard
Vasile, D., Iancu, R., Bogdanici, C., Ungureanu, E., Ciobotea, D., Ciuluvica, R., Iancu, G. (2017). 'Chemo-physical Properties and Biomedical Applications of Hyaluronic Acid in Medicine', Revista de Chimie, 68(2), pp. 384-386. https://doi.org/10.37358/RC.17.2.5458

IEEE
D. Vasile, R. Iancu, C. Bogdanici, E. Ungureanu, D. Ciobotea, R. Ciuluvica, G. Iancu, "Chemo-physical Properties and Biomedical Applications of Hyaluronic Acid in Medicine". Revista de Chimie, vol. 68, no. 2, pp. 384-386, 2017. [online]. https://doi.org/10.37358/RC.17.2.5458

Text
Danut Vasile, Raluca Iancu, Camelia Bogdanici, Emil Ungureanu, Dana Ciobotea, Radu Ciuluvica, George Iancu,
Chemo-physical Properties and Biomedical Applications of Hyaluronic Acid in Medicine,
Revista de Chimie,
Volume 68, Issue 2,
2017,
Pages 384-386,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.2.5458.
(https://revistadechimie.ro/Articles.asp?ID=5458)
Keywords: Hyaluronic acid; Glycosaminoglycan; Viscoelastic properties

RIS
TY - JOUR
T1 - Chemo-physical Properties and Biomedical Applications of Hyaluronic Acid in Medicine
A1 - Vasile, Danut
A2 - Iancu, Raluca
A3 - Bogdanici, Camelia
A4 - Ungureanu, Emil
A5 - Ciobotea, Dana
A6 - Ciuluvica, Radu
A7 - Iancu, George
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 2
SP - 384
EP - 386
UR - https://doi.org/10.37358/RC.17.2.5458
KW - Hyaluronic acid
KW - Glycosaminoglycan
KW - Viscoelastic properties
ER -

BibTex
@article{RevCh2017P384,
author = {Vasile Danut and Iancu Raluca and Bogdanici Camelia and Ungureanu Emil and Ciobotea Dana and Ciuluvica Radu and Iancu George},
title = {Chemo-physical Properties and Biomedical Applications of Hyaluronic Acid in Medicine},
journal = {Revista de Chimie},
volume = {68},
number = {2},
pages = {384-386},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.2.5458},
url = {https://revistadechimie.ro/Articles.asp?ID=5458}
}

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