Local Silver Nanoparticles Administration Promotes Inflammation and Hyperalgesia in Rats

Alexa, Anisia Iuliana; Stratulat, Teodora Alexa; Constantin, Maria Magdalena Leon; Alexa, Ioana Dana; Tamba, Bogdan Ionel

Anisia Iuliana Alexa, Teodora Alexa Stratulat, Maria Magdalena Leon Constantin, Ioana Dana Alexa, Bogdan Ionel Tamba

Local Silver Nanoparticles Administration Promotes Inflammation and Hyperalgesia in Rats

Abstract:

Silver has no known function in the organism. However, nanosilver has the highest degree of commercialization of all nanomaterials used in healthcare. The aim of this study was to assess the potential deleterious effect of local nanosilver administration in an animal model. Wistar rats received a subcutaneous injection (hind paw) of either 500ppm nanosilver (group S1), 20ppm nanosilver (group S2) or saline (control group). Animals were tested by means of plantar test, analgesy-meter and plethysmometer. 24 h after the administration, l-carrageenan was injected (same site), which lead to localized inflammation. The above-mentioned assessments were performed repeatedly until 24 h after l-carrageenan administration. 24 h after colloidal silver administration, both S1 and S2 groups had a significantly higher sensibility to mechanical stimuli. 48 h after colloidal silver administration, the S1 group had a significantly higher sensibility to thermal stimuli. Paw edema was more pronounced in the treatment groups in the first 30 h after the nanosilver injection. Local subcutaneous nanosilver administration leads to an increased inflammatory response and to hyperalgesia. Considering the constant increase in nanosilver’s biomedical use, the current paper sends a clear warning for the need of urgent more in-depth research on the matter.

Keywords:
nanosilver ; l-carrageenan; paw edema; hyperalgesia

Issue: 2017, Volume 68, Issue 3

Pages: 490-495

Publication date: 2017/4/15

https://doi.org/10.37358/RC.17.3.5485

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ALEXA, A.I., STRATULAT, T.A., CONSTANTIN, M.M.L., ALEXA, I.D., TAMBA, B.I., Local Silver Nanoparticles Administration Promotes Inflammation and Hyperalgesia in Rats, Rev. Chim., 68(3), 2017, 490-495.

Vancouver
Alexa AI, Stratulat TA, Constantin MML, Alexa ID, Tamba BI. Local Silver Nanoparticles Administration Promotes Inflammation and Hyperalgesia in Rats. Rev. Chim.[internet]. 2017 Mar;68(3):490-495. Available from: https://doi.org/10.37358/RC.17.3.5485

APA 6th edition
Alexa, A.I., Stratulat, T.A., Constantin, M.M.L., Alexa, I.D. & Tamba, B.I. (2017). Local Silver Nanoparticles Administration Promotes Inflammation and Hyperalgesia in Rats. Revista de Chimie, 68(3), 490-495. https://doi.org/10.37358/RC.17.3.5485

Harvard
Alexa, A.I., Stratulat, T.A., Constantin, M.M.L., Alexa, I.D., Tamba, B.I. (2017). 'Local Silver Nanoparticles Administration Promotes Inflammation and Hyperalgesia in Rats', Revista de Chimie, 68(3), pp. 490-495. https://doi.org/10.37358/RC.17.3.5485

IEEE
A.I. Alexa, T.A. Stratulat, M.M.L. Constantin, I.D. Alexa, B.I. Tamba, "Local Silver Nanoparticles Administration Promotes Inflammation and Hyperalgesia in Rats". Revista de Chimie, vol. 68, no. 3, pp. 490-495, 2017. [online]. https://doi.org/10.37358/RC.17.3.5485

Text
Anisia Iuliana Alexa, Teodora Alexa Stratulat, Maria Magdalena Leon Constantin, Ioana Dana Alexa, Bogdan Ionel Tamba,
Local Silver Nanoparticles Administration Promotes Inflammation and Hyperalgesia in Rats,
Revista de Chimie,
Volume 68, Issue 3,
2017,
Pages 490-495,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.3.5485.
(https://revistadechimie.ro/Articles.asp?ID=5485)
Keywords: nanosilver ; l-carrageenan; paw edema; hyperalgesia

RIS
TY - JOUR
T1 - Local Silver Nanoparticles Administration Promotes Inflammation and Hyperalgesia in Rats
A1 - Alexa, Anisia Iuliana
A2 - Stratulat, Teodora Alexa
A3 - Constantin, Maria Magdalena Leon
A4 - Alexa, Ioana Dana
A5 - Tamba, Bogdan Ionel
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 3
SP - 490
EP - 495
UR - https://doi.org/10.37358/RC.17.3.5485
KW - nanosilver
KW - l-carrageenan
KW - paw edema
KW - hyperalgesia
ER -

BibTex
@article{RevCh2017P490,
author = {Alexa Anisia Iuliana and Stratulat Teodora Alexa and Constantin Maria Magdalena Leon and Alexa Ioana Dana and Tamba Bogdan Ionel},
title = {Local Silver Nanoparticles Administration Promotes Inflammation and Hyperalgesia in Rats},
journal = {Revista de Chimie},
volume = {68},
number = {3},
pages = {490-495},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.3.5485},
url = {https://revistadechimie.ro/Articles.asp?ID=5485}
}

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