Fast and Simple Method for Simultaneous Detection and Quantification of Diazepam and Desmethyldiazepam in Plasma Samples in Psychiatric Patients by GC-MS-FID

Vlad, Cristian Sebastian; Dumitrascu, Victor; Vlad, Daliborca Cristina; Cimporescu, Adinela; Popescu, Roxana; Dehelean, Liana; Marincu, Iosif; Citu, Ioana Mihaela; Poenaru, Dan V.

Cristian Sebastian Vlad, Victor Dumitrascu, Daliborca Cristina Vlad, Adinela Cimporescu, Roxana Popescu, Liana Dehelean, Iosif Marincu, Ioana Mihaela Citu, Dan V. Poenaru

Fast and Simple Method for Simultaneous Detection and Quantification of Diazepam and Desmethyldiazepam in Plasma Samples in Psychiatric Patients by GC-MS-FID

Abstract:

The aim of this study was to develop a method for identification and quantification of diazepam and its major metabolite, desmethyldiazepam in plasma samples in psychiatric patients. Liquid - liquid extraction (LLE) procedure was applied in order to simplify the pre-analytical phase, followed by gas chromatography - mass spectrometry (GC-MS) detection and gas chromatography - flame ionization (GC-FID) quantitation.

Keywords:
liquid-liquid extraction; diazepam; GC-MS-FID

Issue: 2017, Volume 68, Issue 3

Pages: 530-533

Publication date: 2017/4/15

https://doi.org/10.37358/RC.17.3.5495

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
VLAD, C.S., DUMITRASCU, V., VLAD, D.C., CIMPORESCU, A., POPESCU, R., DEHELEAN, L., MARINCU, I., CITU, I.M., POENARU, D.V., Fast and Simple Method for Simultaneous Detection and Quantification of Diazepam and Desmethyldiazepam in Plasma Samples in Psychiatric Patients by GC-MS-FID, Rev. Chim., 68(3), 2017, 530-533.

Vancouver
Vlad CS, Dumitrascu V, Vlad DC, Cimporescu A, Popescu R, Dehelean L, Marincu I, Citu IM, Poenaru DV. Fast and Simple Method for Simultaneous Detection and Quantification of Diazepam and Desmethyldiazepam in Plasma Samples in Psychiatric Patients by GC-MS-FID. Rev. Chim.[internet]. 2017 Mar;68(3):530-533. Available from: https://doi.org/10.37358/RC.17.3.5495

APA 6th edition
Vlad, C.S., Dumitrascu, V., Vlad, D.C., Cimporescu, A., Popescu, R., Dehelean, L.,... Poenaru, D.V. (2017). Fast and Simple Method for Simultaneous Detection and Quantification of Diazepam and Desmethyldiazepam in Plasma Samples in Psychiatric Patients by GC-MS-FID. Revista de Chimie, 68(3), 530-533. https://doi.org/10.37358/RC.17.3.5495

Harvard
Vlad, C.S., Dumitrascu, V., Vlad, D.C., Cimporescu, A., Popescu, R., Dehelean, L., Marincu, I., Citu, I.M., Poenaru, D.V. (2017). 'Fast and Simple Method for Simultaneous Detection and Quantification of Diazepam and Desmethyldiazepam in Plasma Samples in Psychiatric Patients by GC-MS-FID', Revista de Chimie, 68(3), pp. 530-533. https://doi.org/10.37358/RC.17.3.5495

IEEE
C.S. Vlad, V. Dumitrascu, D.C. Vlad, A. Cimporescu, R. Popescu, L. Dehelean, I. Marincu, I.M. Citu, D.V. Poenaru, "Fast and Simple Method for Simultaneous Detection and Quantification of Diazepam and Desmethyldiazepam in Plasma Samples in Psychiatric Patients by GC-MS-FID". Revista de Chimie, vol. 68, no. 3, pp. 530-533, 2017. [online]. https://doi.org/10.37358/RC.17.3.5495

Text
Cristian Sebastian Vlad, Victor Dumitrascu, Daliborca Cristina Vlad, Adinela Cimporescu, Roxana Popescu, Liana Dehelean, Iosif Marincu, Ioana Mihaela Citu, Dan V. Poenaru,
Fast and Simple Method for Simultaneous Detection and Quantification of Diazepam and Desmethyldiazepam in Plasma Samples in Psychiatric Patients by GC-MS-FID,
Revista de Chimie,
Volume 68, Issue 3,
2017,
Pages 530-533,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.3.5495.
(https://revistadechimie.ro/Articles.asp?ID=5495)
Keywords: liquid-liquid extraction; diazepam; GC-MS-FID

RIS
TY - JOUR
T1 - Fast and Simple Method for Simultaneous Detection and Quantification of Diazepam and Desmethyldiazepam in Plasma Samples in Psychiatric Patients by GC-MS-FID
A1 - Vlad, Cristian Sebastian
A2 - Dumitrascu, Victor
A3 - Vlad, Daliborca Cristina
A4 - Cimporescu, Adinela
A5 - Popescu, Roxana
A6 - Dehelean, Liana
A7 - Marincu, Iosif
A8 - Citu, Ioana Mihaela
A9 - Poenaru, Dan V.
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 3
SP - 530
EP - 533
UR - https://doi.org/10.37358/RC.17.3.5495
KW - liquid-liquid extraction
KW - diazepam
KW - GC-MS-FID
ER -

BibTex
@article{RevCh2017P530,
author = {Vlad Cristian Sebastian and Dumitrascu Victor and Vlad Daliborca Cristina and Cimporescu Adinela and Popescu Roxana and Dehelean Liana and Marincu Iosif and Citu Ioana Mihaela and Poenaru Dan V.},
title = {Fast and Simple Method for Simultaneous Detection and Quantification of Diazepam and Desmethyldiazepam in Plasma Samples in Psychiatric Patients by GC-MS-FID},
journal = {Revista de Chimie},
volume = {68},
number = {3},
pages = {530-533},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.3.5495},
url = {https://revistadechimie.ro/Articles.asp?ID=5495}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)

News, Events

Gold Open Access | Source=http://www.plos.org/ | Author=art designer at PLoS

Conferences of Contemporary
Chemistry

Biblioteca Chimiei

Materiale Plastice

REVISTA DE CHIMIE

About

Board

Indexing