Study on the TNF-a, Il-1b and Il-6 Levels in Patients with Chronic Periodontitis and Cardiovascular Diseases

Nicolaiciuc, Ovidiu; Mihai, Constantin; Sufaru, Irina Georgeta; Martu, Ioana; Solomon, Sorina Mihaela; Tatarciuc, Diana; Budacu, Cristian; Martu, Silvia

Ovidiu Nicolaiciuc, Constantin Mihai, Irina Georgeta Sufaru, Ioana Martu, Sorina Mihaela Solomon, Diana Tatarciuc, Cristian Budacu, Silvia Martu

Study on the TNF-a, Il-1b and Il-6 Levels in Patients with Chronic Periodontitis and Cardiovascular Diseases

Abstract:

Studies on the link between periodontal disease and atherosclerosis have generated conflicting results and the mechanisms underlying this relationship are incompletely understood. Therefore, this study aimed to assess the levels in serum and in gingival crevicular fluid (GCF) of TNF-a, IL-1b and IL-6, to clarify the possible link between periodontitis and hyperlipidemia, as well as the effects of conventional periodontal treatment through scaling and root surfacing on these pro-inflammatory molecules. The study was carried out on a total of 40 subjects divided into two main groups: the study group (n=26) and control group (n=14). The cases included patients with atherosclerosis with prescribed diet (D) or antilipemic therapy with a drug from the statin group (S). Controls (C) were selected from systemically healthy subjects with chronic periodontitis. Samples were performed from crevicular fluid and serum, by determining the initial and post-treatment of TNF-a, IL-1b and IL-6. For all groups there were significant serum decreases in TNF-a, IL-1b and IL-6 from baseline, and the decreases were more significant IL-1b for statin group. Significant decreases were found in the crevicular fluid for all cytokines. The decrease was most evident for IL-6 in the statin group. Combining antilipemic periodontal therapy and treatment can provide beneficial effects on metabolism and control of inflammatory atherosclerosis by lowering serum pro-inflammatory cytokines.

Keywords:
TNF-a; IL-1b; IL-6; chronic periodontitis; atherosclerosis

Issue: 2017, Volume 68, Issue 3

Pages: 619-623

Publication date: 2017/4/15

https://doi.org/10.37358/RC.17.3.5515

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
NICOLAICIUC, O., MIHAI, C., SUFARU, I.G., MARTU, I., SOLOMON, S.M., TATARCIUC, D., BUDACU, C., MARTU, S., Study on the TNF-a, Il-1b and Il-6 Levels in Patients with Chronic Periodontitis and Cardiovascular Diseases, Rev. Chim., 68(3), 2017, 619-623.

Vancouver
Nicolaiciuc O, Mihai C, Sufaru IG, Martu I, Solomon SM, Tatarciuc D, Budacu C, Martu S. Study on the TNF-a, Il-1b and Il-6 Levels in Patients with Chronic Periodontitis and Cardiovascular Diseases. Rev. Chim.[internet]. 2017 Mar;68(3):619-623. Available from: https://doi.org/10.37358/RC.17.3.5515

APA 6th edition
Nicolaiciuc, O., Mihai, C., Sufaru, I.G., Martu, I., Solomon, S.M., Tatarciuc, D., Budacu, C. & Martu, S. (2017). Study on the TNF-a, Il-1b and Il-6 Levels in Patients with Chronic Periodontitis and Cardiovascular Diseases. Revista de Chimie, 68(3), 619-623. https://doi.org/10.37358/RC.17.3.5515

Harvard
Nicolaiciuc, O., Mihai, C., Sufaru, I.G., Martu, I., Solomon, S.M., Tatarciuc, D., Budacu, C., Martu, S. (2017). 'Study on the TNF-a, Il-1b and Il-6 Levels in Patients with Chronic Periodontitis and Cardiovascular Diseases', Revista de Chimie, 68(3), pp. 619-623. https://doi.org/10.37358/RC.17.3.5515

IEEE
O. Nicolaiciuc, C. Mihai, I.G. Sufaru, I. Martu, S.M. Solomon, D. Tatarciuc, C. Budacu, S. Martu, "Study on the TNF-a, Il-1b and Il-6 Levels in Patients with Chronic Periodontitis and Cardiovascular Diseases". Revista de Chimie, vol. 68, no. 3, pp. 619-623, 2017. [online]. https://doi.org/10.37358/RC.17.3.5515

Text
Ovidiu Nicolaiciuc, Constantin Mihai, Irina Georgeta Sufaru, Ioana Martu, Sorina Mihaela Solomon, Diana Tatarciuc, Cristian Budacu, Silvia Martu,
Study on the TNF-a, Il-1b and Il-6 Levels in Patients with Chronic Periodontitis and Cardiovascular Diseases,
Revista de Chimie,
Volume 68, Issue 3,
2017,
Pages 619-623,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.3.5515.
(https://revistadechimie.ro/Articles.asp?ID=5515)
Keywords: TNF-a; IL-1b; IL-6; chronic periodontitis; atherosclerosis

RIS
TY - JOUR
T1 - Study on the TNF-a, Il-1b and Il-6 Levels in Patients with Chronic Periodontitis and Cardiovascular Diseases
A1 - Nicolaiciuc, Ovidiu
A2 - Mihai, Constantin
A3 - Sufaru, Irina Georgeta
A4 - Martu, Ioana
A5 - Solomon, Sorina Mihaela
A6 - Tatarciuc, Diana
A7 - Budacu, Cristian
A8 - Martu, Silvia
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 3
SP - 619
EP - 623
UR - https://doi.org/10.37358/RC.17.3.5515
KW - TNF-a
KW - IL-1b
KW - IL-6
KW - chronic periodontitis
KW - atherosclerosis
ER -

BibTex
@article{RevCh2017P619,
author = {Nicolaiciuc Ovidiu and Mihai Constantin and Sufaru Irina Georgeta and Martu Ioana and Solomon Sorina Mihaela and Tatarciuc Diana and Budacu Cristian and Martu Silvia},
title = {Study on the TNF-a, Il-1b and Il-6 Levels in Patients with Chronic Periodontitis and Cardiovascular Diseases},
journal = {Revista de Chimie},
volume = {68},
number = {3},
pages = {619-623},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.3.5515},
url = {https://revistadechimie.ro/Articles.asp?ID=5515}
}

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