The Study of the Correlation Between the Level of Antioxidant, Enzyme Activity and Administration Zinc in Oxidative Stress Induced by Cyclophosphamide

Haliciu, Ana Maria; Folescu, Roxana; Zugun, Florin; Strat, Liliana; Poroch, Vladimir; Zamfir, Carmen Lacramioara

Ana Maria Haliciu, Roxana Folescu, Florin Zugun, Liliana Strat, Vladimir Poroch, Carmen Lacramioara Zamfir

The Study of the Correlation Between the Level of Antioxidant, Enzyme Activity and Administration Zinc in Oxidative Stress Induced by Cyclophosphamide

Abstract:

A well designed targeted chemotherapy is considered one of the goals of anticancer treatment, significantly improving the survival rate, but there is evidence suggesting it may presents significant drawbacks. Oxidative stress is frequently associated with chemotherapeutic agents, generating increased reactive oxygen species which may alter the female genital system. There are numerous opinions suggesting supplemental antioxidants in chemotherapy represent a positive therapeutic strategy. This study aim was to assess if antioxidants as zinc are able to preserve female rat’s genital system in cyclophosphamide (CP) - induced oxidative stress. In experiment there was used 21 female Wistar rats which were randomly divided in three groups: control, cyclophosphamide - administered group and cyclophosphamide-ZnCl2 administered group. After four weeks, blood was collected to determine malondialdehyde (MDA) level and glutathione peroxidase (GPx) activity. Our results suggests that zinc reduces the deleterious effect of oxidative stress on female rats genital system, the decrease of MDA level together with GPx increase being considered as a result of Zn administration.

Keywords:
malondialdehyde; glutathione peroxidase; antioxidants; administered group; therapeutic strategy

Issue: 2017, Volume 68, Issue 3

Pages: 624-626

Publication date: 2017/4/15

https://doi.org/10.37358/RC.17.3.5516

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
HALICIU, A.M., FOLESCU, R., ZUGUN, F., STRAT, L., POROCH, V., ZAMFIR, C.L., The Study of the Correlation Between the Level of Antioxidant, Enzyme Activity and Administration Zinc in Oxidative Stress Induced by Cyclophosphamide, Rev. Chim., 68(3), 2017, 624-626.

Vancouver
Haliciu AM, Folescu R, Zugun F, Strat L, Poroch V, Zamfir CL. The Study of the Correlation Between the Level of Antioxidant, Enzyme Activity and Administration Zinc in Oxidative Stress Induced by Cyclophosphamide. Rev. Chim.[internet]. 2017 Mar;68(3):624-626. Available from: https://doi.org/10.37358/RC.17.3.5516

APA 6th edition
Haliciu, A.M., Folescu, R., Zugun, F., Strat, L., Poroch, V. & Zamfir, C.L. (2017). The Study of the Correlation Between the Level of Antioxidant, Enzyme Activity and Administration Zinc in Oxidative Stress Induced by Cyclophosphamide. Revista de Chimie, 68(3), 624-626. https://doi.org/10.37358/RC.17.3.5516

Harvard
Haliciu, A.M., Folescu, R., Zugun, F., Strat, L., Poroch, V., Zamfir, C.L. (2017). 'The Study of the Correlation Between the Level of Antioxidant, Enzyme Activity and Administration Zinc in Oxidative Stress Induced by Cyclophosphamide', Revista de Chimie, 68(3), pp. 624-626. https://doi.org/10.37358/RC.17.3.5516

IEEE
A.M. Haliciu, R. Folescu, F. Zugun, L. Strat, V. Poroch, C.L. Zamfir, "The Study of the Correlation Between the Level of Antioxidant, Enzyme Activity and Administration Zinc in Oxidative Stress Induced by Cyclophosphamide". Revista de Chimie, vol. 68, no. 3, pp. 624-626, 2017. [online]. https://doi.org/10.37358/RC.17.3.5516

Text
Ana Maria Haliciu, Roxana Folescu, Florin Zugun, Liliana Strat, Vladimir Poroch, Carmen Lacramioara Zamfir,
The Study of the Correlation Between the Level of Antioxidant, Enzyme Activity and Administration Zinc in Oxidative Stress Induced by Cyclophosphamide,
Revista de Chimie,
Volume 68, Issue 3,
2017,
Pages 624-626,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.3.5516.
(https://revistadechimie.ro/Articles.asp?ID=5516)
Keywords: malondialdehyde; glutathione peroxidase; antioxidants; administered group; therapeutic strategy

RIS
TY - JOUR
T1 - The Study of the Correlation Between the Level of Antioxidant, Enzyme Activity and Administration Zinc in Oxidative Stress Induced by Cyclophosphamide
A1 - Haliciu, Ana Maria
A2 - Folescu, Roxana
A3 - Zugun, Florin
A4 - Strat, Liliana
A5 - Poroch, Vladimir
A6 - Zamfir, Carmen Lacramioara
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 3
SP - 624
EP - 626
UR - https://doi.org/10.37358/RC.17.3.5516
KW - malondialdehyde
KW - glutathione peroxidase
KW - antioxidants
KW - administered group
KW - therapeutic strategy
ER -

BibTex
@article{RevCh2017P624,
author = {Haliciu Ana Maria and Folescu Roxana and Zugun Florin and Strat Liliana and Poroch Vladimir and Zamfir Carmen Lacramioara},
title = {The Study of the Correlation Between the Level of Antioxidant, Enzyme Activity and Administration Zinc in Oxidative Stress Induced by Cyclophosphamide},
journal = {Revista de Chimie},
volume = {68},
number = {3},
pages = {624-626},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.3.5516},
url = {https://revistadechimie.ro/Articles.asp?ID=5516}
}

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