Efficiency of Tranexamic Acid in Management of Surgical Orthopedic Bleeding in Patients with Haemophilia

Badulescu, Oana Viola; Tudor, Razvan; Friedl, Wilhelm; Blaj, Mihaela; Sirbu, Paul Dan

Oana Viola Badulescu, Razvan Tudor, Wilhelm Friedl, Mihaela Blaj, Paul Dan Sirbu

Efficiency of Tranexamic Acid in Management of Surgical Orthopedic Bleeding in Patients with Haemophilia

Abstract:

Haemophilia is an inherited bleeding disorder (gonosomala recessive, related to chromosome X, with transmission from carrying women to male descendents) characterised from the clinic point of view by important bleeding, secondary to some minimum and biologic traumas by deficiency of trombo-plastino-formation, consecutive to either a deficit of factor VIII (haemophilia A), or the factor IX (haemophilia B). The most characteristic manifestation of hemophilia is intra-articular - hemarthrosis. Its repetitive character leads to irreversible lesions of the articular structures, inducing lesions of the synovium with degenerative effects over the articular cartilage and destructive effects for the subchondral bone tissue. In time, these lesions require orthopaedic surgery to improve the locomotor activity. Managing an efficient hemostasis is vital during surgery, due to high risk of bleeding triggered by coagulopathy and surgery. Numerous studies carried out underlined the efficiency of the tranexamic acid (TXA) in reducing bleeding, in different surgery branches, by inhibiting the enzymatic degradation of fibrin. In orthopaedic surgery, the tranexamic acid is frequently used in case of hip and knee arthroplasties, reducing the bleeding and blood transfusion necessary to the treatment of posthaemorrhagic anemia. This paper wants to assess the efficiency of the tranexamic acid in realization of hemostasis to another category of patients, haemophiliac patients with indication of total hip and knee endoprosthesis.

Keywords:
haemophilia; total hip replacement; total knee replacement; tranexamic acid

Issue: 2017, Volume 68, Issue 3

Pages: 627-630

Publication date: 2017/4/15

https://doi.org/10.37358/RC.17.3.5517

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BADULESCU, O.V., TUDOR, R., FRIEDL, W., BLAJ, M., SIRBU, P.D., Efficiency of Tranexamic Acid in Management of Surgical Orthopedic Bleeding in Patients with Haemophilia, Rev. Chim., 68(3), 2017, 627-630.

Vancouver
Badulescu OV, Tudor R, Friedl W, Blaj M, Sirbu PD. Efficiency of Tranexamic Acid in Management of Surgical Orthopedic Bleeding in Patients with Haemophilia. Rev. Chim.[internet]. 2017 Mar;68(3):627-630. Available from: https://doi.org/10.37358/RC.17.3.5517

APA 6th edition
Badulescu, O.V., Tudor, R., Friedl, W., Blaj, M. & Sirbu, P.D. (2017). Efficiency of Tranexamic Acid in Management of Surgical Orthopedic Bleeding in Patients with Haemophilia. Revista de Chimie, 68(3), 627-630. https://doi.org/10.37358/RC.17.3.5517

Harvard
Badulescu, O.V., Tudor, R., Friedl, W., Blaj, M., Sirbu, P.D. (2017). 'Efficiency of Tranexamic Acid in Management of Surgical Orthopedic Bleeding in Patients with Haemophilia', Revista de Chimie, 68(3), pp. 627-630. https://doi.org/10.37358/RC.17.3.5517

IEEE
O.V. Badulescu, R. Tudor, W. Friedl, M. Blaj, P.D. Sirbu, "Efficiency of Tranexamic Acid in Management of Surgical Orthopedic Bleeding in Patients with Haemophilia". Revista de Chimie, vol. 68, no. 3, pp. 627-630, 2017. [online]. https://doi.org/10.37358/RC.17.3.5517

Text
Oana Viola Badulescu, Razvan Tudor, Wilhelm Friedl, Mihaela Blaj, Paul Dan Sirbu,
Efficiency of Tranexamic Acid in Management of Surgical Orthopedic Bleeding in Patients with Haemophilia,
Revista de Chimie,
Volume 68, Issue 3,
2017,
Pages 627-630,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.3.5517.
(https://revistadechimie.ro/Articles.asp?ID=5517)
Keywords: haemophilia; total hip replacement; total knee replacement; tranexamic acid

RIS
TY - JOUR
T1 - Efficiency of Tranexamic Acid in Management of Surgical Orthopedic Bleeding in Patients with Haemophilia
A1 - Badulescu, Oana Viola
A2 - Tudor, Razvan
A3 - Friedl, Wilhelm
A4 - Blaj, Mihaela
A5 - Sirbu, Paul Dan
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 3
SP - 627
EP - 630
UR - https://doi.org/10.37358/RC.17.3.5517
KW - haemophilia
KW - total hip replacement
KW - total knee replacement
KW - tranexamic acid
ER -

BibTex
@article{RevCh2017P627,
author = {Badulescu Oana Viola and Tudor Razvan and Friedl Wilhelm and Blaj Mihaela and Sirbu Paul Dan},
title = {Efficiency of Tranexamic Acid in Management of Surgical Orthopedic Bleeding in Patients with Haemophilia},
journal = {Revista de Chimie},
volume = {68},
number = {3},
pages = {627-630},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.3.5517},
url = {https://revistadechimie.ro/Articles.asp?ID=5517}
}

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