The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment
Abstract:
Postoperatory atrial fibrillation (AF) is a common complication after cardiac surgery. Among others cardiac structural changes, epicardial adiposity (EA) and inflammation could be associated with increased cardiovascular risk, including AF. Because there are not enough studies on the association between epicardial fat and inflammation in AF, this paper assesses the association between structural changes in human right atrial appendages (RAA) in patients with and without AF with focus on EA and inflammation. RAA specimens from 20 coronary patients (ages 60 ± 10 years) were divided in 2 groups including patients with and without postoperatory AF. Histological, immunohistochemical (IMH) and morphometrical methods were used for assessing EA, myocardial fatty infiltration, epicardial inflammatory foci, cardiomyocytes size and vacuolation and extent of interstitial fibrosis. Atrial changes were found in most patients from both groups, having higher proportions in postoperatory AF patients. EA extent and myocardial fatty infiltration were twofold to threefold higher in patients with postoperatory AF and associated epicardial mononuclear inflammation. RAA structural changes can indicate the susceptibility to develop postoperatory AF. Currently, EA and inflammation have recently emerged as new independent AF risk factors. So, we proposed to study RAA structural changes, including EA, epicardial inflammatory foci in relation with postoperatory AF frequency.
Cite this article as: BUTCOVAN, D., OBOROCEANU, T., CIMPEANU, C., MIRONESCU, A., HALIGA, R.E., PINZARIU, A.C., LUPUSORU, R.V., POPESCU, E., MOCANU, V., The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment, Rev. Chim., 68(4), 2017, 886-889.
Vancouver Butcovan D, Oboroceanu T, Cimpeanu C, Mironescu A, Haliga RE, Pinzariu AC, Lupusoru RV, Popescu E, Mocanu V. The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment. Rev. Chim.[internet]. 2017 Apr;68(4):886-889. Available from: https://doi.org/10.37358/RC.17.4.5571
APA 6th edition Butcovan, D., Oboroceanu, T., Cimpeanu, C., Mironescu, A., Haliga, R.E., Pinzariu, A.C.,... Mocanu, V. (2017). The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment. Revista de Chimie, 68(4), 886-889. https://doi.org/10.37358/RC.17.4.5571
Harvard Butcovan, D., Oboroceanu, T., Cimpeanu, C., Mironescu, A., Haliga, R.E., Pinzariu, A.C., Lupusoru, R.V., Popescu, E., Mocanu, V. (2017). 'The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment', Revista de Chimie, 68(4), pp. 886-889. https://doi.org/10.37358/RC.17.4.5571
IEEE D. Butcovan, T. Oboroceanu, C. Cimpeanu, A. Mironescu, R.E. Haliga, A.C. Pinzariu, R.V. Lupusoru, E. Popescu, V. Mocanu, "The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment". Revista de Chimie, vol. 68, no. 4, pp. 886-889, 2017. [online]. https://doi.org/10.37358/RC.17.4.5571
Text Doina Butcovan, Teodor Oboroceanu, Ciprian Cimpeanu, Aurel Mironescu, Raluca Ecaterina Haliga, Alin Constantin Pinzariu, Raoul Vasile Lupusoru, Eugenia Popescu, Veronica Mocanu, The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment, Revista de Chimie, Volume 68, Issue 4, 2017, Pages 886-889, ISSN 2668-8212, https://doi.org/10.37358/RC.17.4.5571. (https://revistadechimie.ro/Articles.asp?ID=5571) Keywords: epicardial inflammation; epicardial adiposity; atrial fibrillation; atrial fibrosis; cardiac surgery
RIS TY - JOUR T1 - The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment A1 - Butcovan, Doina A2 - Oboroceanu, Teodor A3 - Cimpeanu, Ciprian A4 - Mironescu, Aurel A5 - Haliga, Raluca Ecaterina A6 - Pinzariu, Alin Constantin A7 - Lupusoru, Raoul Vasile A8 - Popescu, Eugenia A9 - Mocanu, Veronica JF - Revista de Chimie JO - Rev. Chim. PB - Revista de Chimie SRL SN - 2668-8212 Y1 - 2017 VL - 68 IS - 4 SP - 886 EP - 889 UR - https://doi.org/10.37358/RC.17.4.5571 KW - epicardial inflammation KW - epicardial adiposity KW - atrial fibrillation KW - atrial fibrosis KW - cardiac surgery ER -
BibTex @article{RevCh2017P886, author = {Butcovan Doina and Oboroceanu Teodor and Cimpeanu Ciprian and Mironescu Aurel and Haliga Raluca Ecaterina and Pinzariu Alin Constantin and Lupusoru Raoul Vasile and Popescu Eugenia and Mocanu Veronica}, title = {The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment}, journal = {Revista de Chimie}, volume = {68}, number = {4}, pages = {886-889}, year = {2017}, issn = {2668-8212}, doi = {https://doi.org/10.37358/RC.17.4.5571}, url = {https://revistadechimie.ro/Articles.asp?ID=5571} }
