Study Regarding Correlation of the Methanol Intoxication and Tissues Necrosis

Knieling, Anton; Matei, Mioara Calipsoana; Iliescu, Diana Bulgaru; Manea, Cristiana; Diac, Madalina; Chistol, Raluca Ozana; Furnica, Cristina

Anton Knieling, Mioara Calipsoana Matei, Diana Bulgaru Iliescu, Cristiana Manea, Madalina Diac, Raluca Ozana Chistol, Cristina Furnica

Study Regarding Correlation of the Methanol Intoxication and Tissues Necrosis

Abstract:

Methanol intoxication is a potentially fatal medical condition associated with basal ganglia and subcortical white matter necrosis. The authors present the case of a 34 years-old female with putaminal necrosis and haemorrhagic stroke secondary to methanol intoxication. The patient was hospitalized in the intensive care unit with severe metabolic acidosis and bilateral blindness after ingesting an unspecified amount of methanol. Computed tomography (CT) examination performed at hospital admission revealed a hypodense, inhomogeneous aspect of lenticular nuclei with ischemia in observation. In the 18th day post-ingestion the patient went into deep coma and a new CT examination was performed revealing an intracerebral hematoma involving the right lenticular nucleus, right external and extreme capsule, and right insula with uncal herniation. Neurosurgical decompression was attempted with unfavourable outcome and exitus. Necropsy examination revealed bilateral lenticular necrosis and a hematoma between the base of the right lenticular nucleus and insular cortex with destruction of the claustrum, external and extreme capsules. Methanol poisoning (mostly accidental) is not uncommon in our country and its metabolite, the formic acid, is a potent central nervous system toxin. Bilateral lenticular necrosis is a typical finding in methanol intoxication due to formic acid accumulation with decrease in mitochondrial adenosine triphosphate (ATP) synthesis responsible for cellular toxicity.

Keywords:
methanol; formic acid; intoxication; lenticular nuclei; necrosis

Issue: 2017, Volume 68, Issue 5

Pages: 1126-1129

Publication date: 2017/6/15

https://doi.org/10.37358/RC.17.5.5626

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
KNIELING, A., MATEI, M.C., ILIESCU, D.B., MANEA, C., DIAC, M., CHISTOL, R.O., FURNICA, C., Study Regarding Correlation of the Methanol Intoxication and Tissues Necrosis, Rev. Chim., 68(5), 2017, 1126-1129.

Vancouver
Knieling A, Matei MC, Iliescu DB, Manea C, Diac M, Chistol RO, Furnica C. Study Regarding Correlation of the Methanol Intoxication and Tissues Necrosis. Rev. Chim.[internet]. 2017 May;68(5):1126-1129. Available from: https://doi.org/10.37358/RC.17.5.5626

APA 6th edition
Knieling, A., Matei, M.C., Iliescu, D.B., Manea, C., Diac, M., Chistol, R.O. & Furnica, C. (2017). Study Regarding Correlation of the Methanol Intoxication and Tissues Necrosis. Revista de Chimie, 68(5), 1126-1129. https://doi.org/10.37358/RC.17.5.5626

Harvard
Knieling, A., Matei, M.C., Iliescu, D.B., Manea, C., Diac, M., Chistol, R.O., Furnica, C. (2017). 'Study Regarding Correlation of the Methanol Intoxication and Tissues Necrosis', Revista de Chimie, 68(5), pp. 1126-1129. https://doi.org/10.37358/RC.17.5.5626

IEEE
A. Knieling, M.C. Matei, D.B. Iliescu, C. Manea, M. Diac, R.O. Chistol, C. Furnica, "Study Regarding Correlation of the Methanol Intoxication and Tissues Necrosis". Revista de Chimie, vol. 68, no. 5, pp. 1126-1129, 2017. [online]. https://doi.org/10.37358/RC.17.5.5626

Text
Anton Knieling, Mioara Calipsoana Matei, Diana Bulgaru Iliescu, Cristiana Manea, Madalina Diac, Raluca Ozana Chistol, Cristina Furnica,
Study Regarding Correlation of the Methanol Intoxication and Tissues Necrosis,
Revista de Chimie,
Volume 68, Issue 5,
2017,
Pages 1126-1129,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.5.5626.
(https://revistadechimie.ro/Articles.asp?ID=5626)
Keywords: methanol; formic acid; intoxication; lenticular nuclei; necrosis

RIS
TY - JOUR
T1 - Study Regarding Correlation of the Methanol Intoxication and Tissues Necrosis
A1 - Knieling, Anton
A2 - Matei, Mioara Calipsoana
A3 - Iliescu, Diana Bulgaru
A4 - Manea, Cristiana
A5 - Diac, Madalina
A6 - Chistol, Raluca Ozana
A7 - Furnica, Cristina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 5
SP - 1126
EP - 1129
UR - https://doi.org/10.37358/RC.17.5.5626
KW - methanol
KW - formic acid
KW - intoxication
KW - lenticular nuclei
KW - necrosis
ER -

BibTex
@article{RevCh2017P1126,
author = {Knieling Anton and Matei Mioara Calipsoana and Iliescu Diana Bulgaru and Manea Cristiana and Diac Madalina and Chistol Raluca Ozana and Furnica Cristina},
title = {Study Regarding Correlation of the Methanol Intoxication and Tissues Necrosis},
journal = {Revista de Chimie},
volume = {68},
number = {5},
pages = {1126-1129},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.5.5626},
url = {https://revistadechimie.ro/Articles.asp?ID=5626}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)