Synthesis and Structure of a New Class of Fused Heterocycle with 8,9-Dihydro-pyridazino<1,2,4>triazine Skeleton

Humelnicu, Ionel; Vasilache, Violeta

Ionel Humelnicu, Violeta Vasilache

Synthesis and Structure of a New Class of Fused Heterocycle with 8,9-Dihydro-pyridazino<1,2,4>triazine Skeleton

Abstract:

The synthesis and X-ray crystal structure of a new class of fused heterocycle with 8,9-dihydro-pyridazino[1,2,4]triazine type 2 is reported. The synthesis is facile and efficient and, the structure of compounds was proven by elemental and spectral analysis, the X-ray spectra including (for 2b). The compound crystallizes in the space group P21/N (monoclinic) with a = 9.0077(2) Å, b = 10.20019(18) Å, c = 14.0099(3) Å, a= 90°, b = 89.768(2)°, g= 90°, V= 1287.22(5) and Z = 4. Accurate molecular parameters for the heterocyclic system were obtained from intensity data collected at 200(14) K. The molecule 8,9-dihydro-pyridazino[1,2,4]triazine type 2 is a noncoplanar bicyclic fused system, with an envelope shape onto the triazine moiety, the C12 carbon being out of plane. The methyl group from the C12 carbon it is almost perpendicular on the triazine plane. We also notice a rather powerful hydrogen bond between hydrogen atom from N1 and the oxygen from the C11=O1 carbonyl group.

Keywords:
8;9-dihydro-pyridazino<1;2;4>triazine; pyridazinone; X-ray; noncoplanar bicyclic fused structure; hydrogen bond

Issue: 2017, Volume 68, Issue 6

Pages: 1159-1162

Publication date: 2017/7/15

https://doi.org/10.37358/RC.17.6.5633

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
HUMELNICU, I., VASILACHE, V., Synthesis and Structure of a New Class of Fused Heterocycle with 8,9-Dihydro-pyridazino<1,2,4>triazine Skeleton, Rev. Chim., 68(6), 2017, 1159-1162.

Vancouver
Humelnicu I, Vasilache V. Synthesis and Structure of a New Class of Fused Heterocycle with 8,9-Dihydro-pyridazino<1,2,4>triazine Skeleton. Rev. Chim.[internet]. 2017 Jun;68(6):1159-1162. Available from: https://doi.org/10.37358/RC.17.6.5633

APA 6th edition
Humelnicu, I., Vasilache, V. (2017). Synthesis and Structure of a New Class of Fused Heterocycle with 8,9-Dihydro-pyridazino<1,2,4>triazine Skeleton. Revista de Chimie, 68(6), 1159-1162. https://doi.org/10.37358/RC.17.6.5633

Harvard
Humelnicu, I., Vasilache, V. (2017). 'Synthesis and Structure of a New Class of Fused Heterocycle with 8,9-Dihydro-pyridazino<1,2,4>triazine Skeleton', Revista de Chimie, 68(6), pp. 1159-1162. https://doi.org/10.37358/RC.17.6.5633

IEEE
I. Humelnicu, V. Vasilache, "Synthesis and Structure of a New Class of Fused Heterocycle with 8,9-Dihydro-pyridazino<1,2,4>triazine Skeleton". Revista de Chimie, vol. 68, no. 6, pp. 1159-1162, 2017. [online]. https://doi.org/10.37358/RC.17.6.5633

Text
Ionel Humelnicu, Violeta Vasilache,
Synthesis and Structure of a New Class of Fused Heterocycle with 8,9-Dihydro-pyridazino<1,2,4>triazine Skeleton,
Revista de Chimie,
Volume 68, Issue 6,
2017,
Pages 1159-1162,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.6.5633.
(https://revistadechimie.ro/Articles.asp?ID=5633)
Keywords: 8;9-dihydro-pyridazino<1;2;4>triazine; pyridazinone; X-ray; noncoplanar bicyclic fused structure; hydrogen bond

RIS
TY - JOUR
T1 - Synthesis and Structure of a New Class of Fused Heterocycle with 8,9-Dihydro-pyridazino<1,2,4>triazine Skeleton
A1 - Humelnicu, Ionel
A2 - Vasilache, Violeta
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 6
SP - 1159
EP - 1162
UR - https://doi.org/10.37358/RC.17.6.5633
KW - 8
KW - 9-dihydro-pyridazino<1
KW - 2
KW - 4>triazine
KW - pyridazinone
KW - X-ray
KW - noncoplanar bicyclic fused structure
KW - hydrogen bond
ER -

BibTex
@article{RevCh2017P1159,
author = {Humelnicu Ionel and Vasilache Violeta},
title = {Synthesis and Structure of a New Class of Fused Heterocycle with 8,9-Dihydro-pyridazino<1,2,4>triazine Skeleton},
journal = {Revista de Chimie},
volume = {68},
number = {6},
pages = {1159-1162},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.6.5633},
url = {https://revistadechimie.ro/Articles.asp?ID=5633}
}

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