1H-NMR Study of Famotidine and Nizatidine Complexes with b-cyclodextrin

Nita, Adriana; Tit, Delia Mirela; Copolovici, Lucian; Melinte (Frunzulica), Carmen Elena; Copolovici, Dana; Bungau, Simona

Adriana Nita, Delia Mirela Tit, Lucian Copolovici, Carmen Elena Melinte (Frunzulica), Dana Copolovici, Simona Bungau

1H-NMR Study of Famotidine and Nizatidine Complexes with b-cyclodextrin

Abstract:

The aim of this study was to obtain and to characterize some inclusion complexes of famotidine and nizatidine with b-cyclodextrin (b-CD) in solution. The formation of famotidine- and nizatidine - b-CD complexes were evaluated by means of 1H-NMR spectroscopy. Thereafter, the stoichiometry and association constants of the complexes obtained were calculated via a continuous variation method by using the chemical shifts of specific protons from both host and guest molecules. The association constants calculated are 179.6 M--1for famotidine - b-cyclodextrin complex, and 74.9 M-1 for nizatidine - b-cyclodextrin complex, at 295 K. Due to their better stability, these complexes could be use as oral pharmaceutical preparations with better taste compared with that of free drugs.

Keywords:
1H-NMR spectroscopy; b-cyclodextrin; famotidine; nizatidine

Issue: 2017, Volume 68, Issue 6

Pages: 1170-1173

Publication date: 2017/7/15

https://doi.org/10.37358/RC.17.6.5635

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Citation Styles

Cite this article as:
NITA, A., TIT, D.M., COPOLOVICI, L., MELINTE (FRUNZULICA), C.E., COPOLOVICI, D., BUNGAU, S., 1H-NMR Study of Famotidine and Nizatidine Complexes with b-cyclodextrin, Rev. Chim., 68(6), 2017, 1170-1173.

Vancouver
Nita A, Tit DM, Copolovici L, Melinte (Frunzulica) CE, Copolovici D, Bungau S. 1H-NMR Study of Famotidine and Nizatidine Complexes with b-cyclodextrin. Rev. Chim.[internet]. 2017 Jun;68(6):1170-1173. Available from: https://doi.org/10.37358/RC.17.6.5635

APA 6th edition
Nita, A., Tit, D.M., Copolovici, L., Melinte (Frunzulica), C.E., Copolovici, D. & Bungau, S. (2017). 1H-NMR Study of Famotidine and Nizatidine Complexes with b-cyclodextrin. Revista de Chimie, 68(6), 1170-1173. https://doi.org/10.37358/RC.17.6.5635

Harvard
Nita, A., Tit, D.M., Copolovici, L., Melinte (Frunzulica), C.E., Copolovici, D., Bungau, S. (2017). '1H-NMR Study of Famotidine and Nizatidine Complexes with b-cyclodextrin', Revista de Chimie, 68(6), pp. 1170-1173. https://doi.org/10.37358/RC.17.6.5635

IEEE
A. Nita, D.M. Tit, L. Copolovici, C.E. Melinte(Frunzulica), D. Copolovici, S. Bungau, "1H-NMR Study of Famotidine and Nizatidine Complexes with b-cyclodextrin". Revista de Chimie, vol. 68, no. 6, pp. 1170-1173, 2017. [online]. https://doi.org/10.37358/RC.17.6.5635

Text
Adriana Nita, Delia Mirela Tit, Lucian Copolovici, Carmen Elena Melinte(Frunzulica), Dana Copolovici, Simona Bungau,
1H-NMR Study of Famotidine and Nizatidine Complexes with b-cyclodextrin,
Revista de Chimie,
Volume 68, Issue 6,
2017,
Pages 1170-1173,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.6.5635.
(https://revistadechimie.ro/Articles.asp?ID=5635)
Keywords: 1H-NMR spectroscopy; b-cyclodextrin; famotidine; nizatidine

RIS
TY - JOUR
T1 - 1H-NMR Study of Famotidine and Nizatidine Complexes with b-cyclodextrin
A1 - Nita, Adriana
A2 - Tit, Delia Mirela
A3 - Copolovici, Lucian
A4 - Melinte (Frunzulica), Carmen Elena
A5 - Copolovici, Dana
A6 - Bungau, Simona
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 6
SP - 1170
EP - 1173
UR - https://doi.org/10.37358/RC.17.6.5635
KW - 1H-NMR spectroscopy
KW - b-cyclodextrin
KW - famotidine
KW - nizatidine
ER -

BibTex
@article{RevCh2017P1170,
author = {Nita Adriana and Tit Delia Mirela and Copolovici Lucian and Melinte (Frunzulica) Carmen Elena and Copolovici Dana and Bungau Simona},
title = {1H-NMR Study of Famotidine and Nizatidine Complexes with b-cyclodextrin},
journal = {Revista de Chimie},
volume = {68},
number = {6},
pages = {1170-1173},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.6.5635},
url = {https://revistadechimie.ro/Articles.asp?ID=5635}
}

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