The Important Roles of Matrix Metalloproteinases in the Pathophysiology of Obesity

Mirica, Radu Mihail; Ionescu, Mihai; Mirica, Alexandra; Ginghina, Octav; Iosifescu, Razvan; Rosca, adrian; Stefan, Daciana Andrada Costina; Iordache, Nicolae; Zagrean, Leon

Radu Mihail Mirica, Mihai Ionescu, Alexandra Mirica, Octav Ginghina, Razvan Iosifescu,adrian Rosca, Daciana Andrada Costina Stefan, Nicolae Iordache, Leon Zagrean

The Important Roles of Matrix Metalloproteinases in the Pathophysiology of Obesity

Abstract:

Obesity involves the growth of adipose tissue cells (adipocytes and preadipocytes), as well as microvascular endothelial cells. Matrix metalloproteinases (MMPs) are relevant ezymes for the modulation of extracellular matrix (ECM) and adipocyte and preadipocytes differentiation. They are elevated in obese patients, generating abnormal ECM metabolism.[1]. This article proposes a thorough study of literature with focus on the important roles of matrix metalloproteinases in the pathophysiology of obesity. The article represents a narrative review based on an English-language PubMed research of the medical literature regardind important aspects of the proposed aim. MMP-2 activity was signiûcantly higher than MMP-9, both activities were detectable. MMP-9 was strongly correlated with body weight parameters before surgery, as well as after significant body weight reduction as a result of bariatric surgery. Concerning MMP-2 and MMP-9 they are also involved in the turnover of basement membranes both those of adipose tissue and endothelial. MMP-9 levels were moderately correlated with HDL cholesterol levels. Taken together, the present data suggest that changes in ECM through MMP-mediated degradation might play a critical role in the adipocyte differentiation process. These findings are detected both in clinical trials and in laboratory animal experiments. It is then tempting to speculate that the adipocyte-derived MMPs might represent a new pharmacological target for the inhibition of adipose tissue growth by inhibiting adipose differentiation as well as angiogenic process.

Keywords:
matrix metalloproteinases; bariatric surgery; adipocyte; preadipocytes

Issue: 2017, Volume 68, Issue 7

Pages: 1481-1484

Publication date: 2017/8/15

https://doi.org/10.37358/RC.17.7.5700

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MIRICA, R.M., IONESCU, M., MIRICA, A., GINGHINA, O., IOSIFESCU, R., ROSCA, A., STEFAN, D.A.C., IORDACHE, N., ZAGREAN, L., The Important Roles of Matrix Metalloproteinases in the Pathophysiology of Obesity, Rev. Chim., 68(7), 2017, 1481-1484.

Vancouver
Mirica RM, Ionescu M, Mirica A, Ginghina O, Iosifescu R, Rosca a, Stefan DAC, Iordache N, Zagrean L. The Important Roles of Matrix Metalloproteinases in the Pathophysiology of Obesity. Rev. Chim.[internet]. 2017 Jul;68(7):1481-1484. Available from: https://doi.org/10.37358/RC.17.7.5700

APA 6th edition
Mirica, R.M., Ionescu, M., Mirica, A., Ginghina, O., Iosifescu, R., Rosca, a.,... Zagrean, L. (2017). The Important Roles of Matrix Metalloproteinases in the Pathophysiology of Obesity. Revista de Chimie, 68(7), 1481-1484. https://doi.org/10.37358/RC.17.7.5700

Harvard
Mirica, R.M., Ionescu, M., Mirica, A., Ginghina, O., Iosifescu, R., Rosca, a., Stefan, D.A.C., Iordache, N., Zagrean, L. (2017). 'The Important Roles of Matrix Metalloproteinases in the Pathophysiology of Obesity', Revista de Chimie, 68(7), pp. 1481-1484. https://doi.org/10.37358/RC.17.7.5700

IEEE
R.M. Mirica, M. Ionescu, A. Mirica, O. Ginghina, R. Iosifescu, a. Rosca, D.A.C. Stefan, N. Iordache, L. Zagrean, "The Important Roles of Matrix Metalloproteinases in the Pathophysiology of Obesity". Revista de Chimie, vol. 68, no. 7, pp. 1481-1484, 2017. [online]. https://doi.org/10.37358/RC.17.7.5700

Text
Radu Mihail Mirica, Mihai Ionescu, Alexandra Mirica, Octav Ginghina, Razvan Iosifescu,adrian Rosca, Daciana Andrada Costina Stefan, Nicolae Iordache, Leon Zagrean,
The Important Roles of Matrix Metalloproteinases in the Pathophysiology of Obesity,
Revista de Chimie,
Volume 68, Issue 7,
2017,
Pages 1481-1484,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.7.5700.
(https://revistadechimie.ro/Articles.asp?ID=5700)
Keywords: matrix metalloproteinases; bariatric surgery; adipocyte; preadipocytes

RIS
TY - JOUR
T1 - The Important Roles of Matrix Metalloproteinases in the Pathophysiology of Obesity
A1 - Mirica, Radu Mihail
A2 - Ionescu, Mihai
A3 - Mirica, Alexandra
A4 - Ginghina, Octav
A5 - Iosifescu, Razvan
A6 - Rosca, adrian
A7 - Stefan, Daciana Andrada Costina
A8 - Iordache, Nicolae
A9 - Zagrean, Leon
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 7
SP - 1481
EP - 1484
UR - https://doi.org/10.37358/RC.17.7.5700
KW - matrix metalloproteinases
KW - bariatric surgery
KW - adipocyte
KW - preadipocytes
ER -

BibTex
@article{RevCh2017P1481,
author = {Mirica Radu Mihail and Ionescu Mihai and Mirica Alexandra and Ginghina Octav and Iosifescu Razvan and Rosca adrian and Stefan Daciana Andrada Costina and Iordache Nicolae and Zagrean Leon},
title = {The Important Roles of Matrix Metalloproteinases in the Pathophysiology of Obesity},
journal = {Revista de Chimie},
volume = {68},
number = {7},
pages = {1481-1484},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.7.5700},
url = {https://revistadechimie.ro/Articles.asp?ID=5700}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)