Periodontal Disease in Patients with Ankylosing Spondylitis: myth or reality?

Iordache, Cristina; Chirieac, Rodica; Ancuta, Eugen; Pomirleanu, Cristina; Ancuta, Codrina

Cristina Iordache, Rodica Chirieac, Eugen Ancuta, Cristina Pomirleanu, Codrina Ancuta

Periodontal Disease in Patients with Ankylosing Spondylitis: myth or reality?

Abstract:

Although the relation between periodontitis (PD) and systemic disorders (e.g. cardiovascular diseases, diabetes and rheumatoid arthritis) is widely accepted, the association with ankylosing spondylitis (AS) is inconsistently mentioned. We prospectively examined the relationship between periodontal disease and AS, focusing on the rate and course of PD, factors associated with severity and the impact of anti-TNF-a treatment on inflammatory status. Standard assessments performed twice (week 0, week 24) included an extensive dental evaluation (plaque index, gingival index, bleeding on probing, periodontal pocket depth, clinical attachment loss), inflammatory parameters and AS activity scores (BASDAI, ASDAS-CRP). More than half of AS presented with impaired periodontal health at baseline (mild to moderate PD) meaning increased sites with dental plaque, abnormal bleeding, increased periodontal pocket depth and clinical attachment loss. Significant positive correlation between presence and severity of PD, AS activity and systemic inflammation (CRP) was reported at baseline (p[0.05). A final analysis performed at 24 weeks revealed significant improvement in periodontal status, inflammatory parameters and AS activity, suggesting efficacy of TNF inhibitors directed not only against systemic, but also on local (articular, periodontal) inflammation (p[0.05). Patients with AS are at risk to develop periodontal disease, particularly those with high levels of systemic inflammation. Benefits of anti-TNFa therapy in the particular settings of AS patient and concomitant periodontal disease should be validated through further studies in larger cohorts.

Keywords:
ankylosing spondylitis; periodontitis; TNF antagonists

Issue: 2017, Volume 68, Issue 7

Pages: 1660-1664

Publication date: 2017/8/15

https://doi.org/10.37358/RC.17.7.5740

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
IORDACHE, C., CHIRIEAC, R., ANCUTA, E., POMIRLEANU, C., ANCUTA, C., Periodontal Disease in Patients with Ankylosing Spondylitis: myth or reality?, Rev. Chim., 68(7), 2017, 1660-1664.

Vancouver
Iordache C, Chirieac R, Ancuta E, Pomirleanu C, Ancuta C. Periodontal Disease in Patients with Ankylosing Spondylitis: myth or reality?. Rev. Chim.[internet]. 2017 Jul;68(7):1660-1664. Available from: https://doi.org/10.37358/RC.17.7.5740

APA 6th edition
Iordache, C., Chirieac, R., Ancuta, E., Pomirleanu, C. & Ancuta, C. (2017). Periodontal Disease in Patients with Ankylosing Spondylitis: myth or reality?. Revista de Chimie, 68(7), 1660-1664. https://doi.org/10.37358/RC.17.7.5740

Harvard
Iordache, C., Chirieac, R., Ancuta, E., Pomirleanu, C., Ancuta, C. (2017). 'Periodontal Disease in Patients with Ankylosing Spondylitis: myth or reality?', Revista de Chimie, 68(7), pp. 1660-1664. https://doi.org/10.37358/RC.17.7.5740

IEEE
C. Iordache, R. Chirieac, E. Ancuta, C. Pomirleanu, C. Ancuta, "Periodontal Disease in Patients with Ankylosing Spondylitis: myth or reality?". Revista de Chimie, vol. 68, no. 7, pp. 1660-1664, 2017. [online]. https://doi.org/10.37358/RC.17.7.5740

Text
Cristina Iordache, Rodica Chirieac, Eugen Ancuta, Cristina Pomirleanu, Codrina Ancuta,
Periodontal Disease in Patients with Ankylosing Spondylitis: myth or reality?,
Revista de Chimie,
Volume 68, Issue 7,
2017,
Pages 1660-1664,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.7.5740.
(https://revistadechimie.ro/Articles.asp?ID=5740)
Keywords: ankylosing spondylitis; periodontitis; TNF antagonists

RIS
TY - JOUR
T1 - Periodontal Disease in Patients with Ankylosing Spondylitis: myth or reality?
A1 - Iordache, Cristina
A2 - Chirieac, Rodica
A3 - Ancuta, Eugen
A4 - Pomirleanu, Cristina
A5 - Ancuta, Codrina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 7
SP - 1660
EP - 1664
UR - https://doi.org/10.37358/RC.17.7.5740
KW - ankylosing spondylitis
KW - periodontitis
KW - TNF antagonists
ER -

BibTex
@article{RevCh2017P1660,
author = {Iordache Cristina and Chirieac Rodica and Ancuta Eugen and Pomirleanu Cristina and Ancuta Codrina},
title = {Periodontal Disease in Patients with Ankylosing Spondylitis: myth or reality?},
journal = {Revista de Chimie},
volume = {68},
number = {7},
pages = {1660-1664},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.7.5740},
url = {https://revistadechimie.ro/Articles.asp?ID=5740}
}

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