Strontium Ranelate in the Healing of Fractures Complicated with Delayed Union. It is Really Effective?

Sirbu, Paul Dan; Tudor, Razvan; Veringa, Vlad; Ciuntu, Bogdan Mihnea; Radu, Valentin; Ciubara, Bogdan; Badulescu, Oana Viola

Paul Dan Sirbu, Razvan Tudor, Vlad Veringa, Bogdan Mihnea Ciuntu, Valentin Radu, Bogdan Ciubara, Oana Viola Badulescu

Strontium Ranelate in the Healing of Fractures Complicated with Delayed Union. It is Really Effective?

Abstract:

Osteoporosis is a systemic skeletal disease characterized by low bone strength, which leads to an increased risk of fracture. The primary objective of osteoporosis treatment is the prevention of fragility fractures and the secondary objective is their rapid healing if they occur. Strontium ranelate is an antiosteoporotic therapeutic agent with a double action mechanism: the increase of bone formation and the decrease of bone resorption, contributing thus to the improvement of bone healing. Preclinical studies have demonstrated the efficacy of strontium ranelate for the improvement of bone healing and bone microarhitecture, as well as of the osteointegration of implants. Some clinical cases have been reported regarding the efficacy of strontium ranelate in the healing of long bone fractures complicated by nonunion or delayed union. In the present study we have reported 2 clinical cases that demonstrate the effectiveness of the treatment with strontium ranelate (Osseor) for 3-6 months in the healing of complicated long bone fractures with delayed union. Our cases confirm the results of the open label study CL3-12911-036 (delayed union and non-union fracture study), where the treatment with 2 g/day of strontium ranelate improved healing and led to a better quality of life. Even if there are some cardiovascular contraindications, strontium ranelate is proven to reduce vertebral and non-vertebral fracture risk in osteoporosis and in the same time improves bone microarchitecture and accelerates fracture healing.

Keywords:
Strontium ranelate; osteoporosis; bone formation; delayed union; fragility fractures

Issue: 2017, Volume 68, Issue 8

Pages: 1825-1828

Publication date: 2017/9/15

https://doi.org/10.37358/RC.17.8.5774

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
SIRBU, P.D., TUDOR, R., VERINGA, V., CIUNTU, B.M., RADU, V., CIUBARA, B., BADULESCU, O.V., Strontium Ranelate in the Healing of Fractures Complicated with Delayed Union. It is Really Effective?, Rev. Chim., 68(8), 2017, 1825-1828.

Vancouver
Sirbu PD, Tudor R, Veringa V, Ciuntu BM, Radu V, Ciubara B, Badulescu OV. Strontium Ranelate in the Healing of Fractures Complicated with Delayed Union. It is Really Effective?. Rev. Chim.[internet]. 2017 Aug;68(8):1825-1828. Available from: https://doi.org/10.37358/RC.17.8.5774

APA 6th edition
Sirbu, P.D., Tudor, R., Veringa, V., Ciuntu, B.M., Radu, V., Ciubara, B. & Badulescu, O.V. (2017). Strontium Ranelate in the Healing of Fractures Complicated with Delayed Union. It is Really Effective?. Revista de Chimie, 68(8), 1825-1828. https://doi.org/10.37358/RC.17.8.5774

Harvard
Sirbu, P.D., Tudor, R., Veringa, V., Ciuntu, B.M., Radu, V., Ciubara, B., Badulescu, O.V. (2017). 'Strontium Ranelate in the Healing of Fractures Complicated with Delayed Union. It is Really Effective?', Revista de Chimie, 68(8), pp. 1825-1828. https://doi.org/10.37358/RC.17.8.5774

IEEE
P.D. Sirbu, R. Tudor, V. Veringa, B.M. Ciuntu, V. Radu, B. Ciubara, O.V. Badulescu, "Strontium Ranelate in the Healing of Fractures Complicated with Delayed Union. It is Really Effective?". Revista de Chimie, vol. 68, no. 8, pp. 1825-1828, 2017. [online]. https://doi.org/10.37358/RC.17.8.5774

Text
Paul Dan Sirbu, Razvan Tudor, Vlad Veringa, Bogdan Mihnea Ciuntu, Valentin Radu, Bogdan Ciubara, Oana Viola Badulescu,
Strontium Ranelate in the Healing of Fractures Complicated with Delayed Union. It is Really Effective?,
Revista de Chimie,
Volume 68, Issue 8,
2017,
Pages 1825-1828,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.8.5774.
(https://revistadechimie.ro/Articles.asp?ID=5774)
Keywords: Strontium ranelate; osteoporosis; bone formation; delayed union; fragility fractures

RIS
TY - JOUR
T1 - Strontium Ranelate in the Healing of Fractures Complicated with Delayed Union. It is Really Effective?
A1 - Sirbu, Paul Dan
A2 - Tudor, Razvan
A3 - Veringa, Vlad
A4 - Ciuntu, Bogdan Mihnea
A5 - Radu, Valentin
A6 - Ciubara, Bogdan
A7 - Badulescu, Oana Viola
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 8
SP - 1825
EP - 1828
UR - https://doi.org/10.37358/RC.17.8.5774
KW - Strontium ranelate
KW - osteoporosis
KW - bone formation
KW - delayed union
KW - fragility fractures
ER -

BibTex
@article{RevCh2017P1825,
author = {Sirbu Paul Dan and Tudor Razvan and Veringa Vlad and Ciuntu Bogdan Mihnea and Radu Valentin and Ciubara Bogdan and Badulescu Oana Viola},
title = {Strontium Ranelate in the Healing of Fractures Complicated with Delayed Union. It is Really Effective?},
journal = {Revista de Chimie},
volume = {68},
number = {8},
pages = {1825-1828},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.8.5774},
url = {https://revistadechimie.ro/Articles.asp?ID=5774}
}

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