Matrix Metalloproteinase and Their Inhibitors Concentration and Activity Variations in Aqueous Humor and Plasma of Glaucoma Patients

Ciotu, Iulia Maria; Constantin, Alina; Voinea, Liliana; Atanasiu, Valeriu

Iulia Maria Ciotu, Alina Constantin, Liliana Voinea, Valeriu Atanasiu

Matrix Metalloproteinase and Their Inhibitors Concentration and Activity Variations in Aqueous Humor and Plasma of Glaucoma Patients

Abstract:

Matrix metalloproteinases (MMPs) are a group of endopeptidases with the role of reorganizing the extracellular matrix of cells through the body. In aqueous humor MMPs have an important role in turnover regulation by acting on the constant remodeling of the trabecular mesh keeping at a constant level the trabecular resistance for a good aqueous humor outflow and consequently of the intraocular pressure.In this paper, we aimed to assess the levels of MMP-2/TIMP-1 and MMP-9/TIMP-2 ratio in aqueous humor samples and in the plasma of patients with open angle glaucoma and cataract patients that serves as control, and to evaluate the gelatinolytic activity MMP-2 and MMP-9 in aqueous humor samples. Aqueous humor and plasma samples were collected from 30 patients, 14 from open angle glaucoma and 16 from cataract patients. Levels of MMP-2, -9 and TIMP -1 and -2 were determined by zymography and immunoassays, using specific kits. The data obtained suggest the presence of a direct correlation between the levels and activity of MMP influencing the accumulation of abnormal matrix and may have an impact on the pathogenesis of open angle glaucoma.

Keywords:
open angle glaucoma; matrix metalloproteinase; tissue inhibitors of matrix metalloproteinase

Issue: 2017, Volume 68, Issue 8

Pages: 1829-1833

Publication date: 2017/9/15

https://doi.org/10.37358/RC.17.8.5775

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
CIOTU, I.M., CONSTANTIN, A., VOINEA, L., ATANASIU, V., Matrix Metalloproteinase and Their Inhibitors Concentration and Activity Variations in Aqueous Humor and Plasma of Glaucoma Patients, Rev. Chim., 68(8), 2017, 1829-1833.

Vancouver
Ciotu IM, Constantin A, Voinea L, Atanasiu V. Matrix Metalloproteinase and Their Inhibitors Concentration and Activity Variations in Aqueous Humor and Plasma of Glaucoma Patients. Rev. Chim.[internet]. 2017 Aug;68(8):1829-1833. Available from: https://doi.org/10.37358/RC.17.8.5775

APA 6th edition
Ciotu, I.M., Constantin, A., Voinea, L. & Atanasiu, V. (2017). Matrix Metalloproteinase and Their Inhibitors Concentration and Activity Variations in Aqueous Humor and Plasma of Glaucoma Patients. Revista de Chimie, 68(8), 1829-1833. https://doi.org/10.37358/RC.17.8.5775

Harvard
Ciotu, I.M., Constantin, A., Voinea, L., Atanasiu, V. (2017). 'Matrix Metalloproteinase and Their Inhibitors Concentration and Activity Variations in Aqueous Humor and Plasma of Glaucoma Patients', Revista de Chimie, 68(8), pp. 1829-1833. https://doi.org/10.37358/RC.17.8.5775

IEEE
I.M. Ciotu, A. Constantin, L. Voinea, V. Atanasiu, "Matrix Metalloproteinase and Their Inhibitors Concentration and Activity Variations in Aqueous Humor and Plasma of Glaucoma Patients". Revista de Chimie, vol. 68, no. 8, pp. 1829-1833, 2017. [online]. https://doi.org/10.37358/RC.17.8.5775

Text
Iulia Maria Ciotu, Alina Constantin, Liliana Voinea, Valeriu Atanasiu,
Matrix Metalloproteinase and Their Inhibitors Concentration and Activity Variations in Aqueous Humor and Plasma of Glaucoma Patients,
Revista de Chimie,
Volume 68, Issue 8,
2017,
Pages 1829-1833,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.8.5775.
(https://revistadechimie.ro/Articles.asp?ID=5775)
Keywords: open angle glaucoma; matrix metalloproteinase; tissue inhibitors of matrix metalloproteinase

RIS
TY - JOUR
T1 - Matrix Metalloproteinase and Their Inhibitors Concentration and Activity Variations in Aqueous Humor and Plasma of Glaucoma Patients
A1 - Ciotu, Iulia Maria
A2 - Constantin, Alina
A3 - Voinea, Liliana
A4 - Atanasiu, Valeriu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 8
SP - 1829
EP - 1833
UR - https://doi.org/10.37358/RC.17.8.5775
KW - open angle glaucoma
KW - matrix metalloproteinase
KW - tissue inhibitors of matrix metalloproteinase
ER -

BibTex
@article{RevCh2017P1829,
author = {Ciotu Iulia Maria and Constantin Alina and Voinea Liliana and Atanasiu Valeriu},
title = {Matrix Metalloproteinase and Their Inhibitors Concentration and Activity Variations in Aqueous Humor and Plasma of Glaucoma Patients},
journal = {Revista de Chimie},
volume = {68},
number = {8},
pages = {1829-1833},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.8.5775},
url = {https://revistadechimie.ro/Articles.asp?ID=5775}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)