Biochemical Effects of Some Tyrosine Kinase Inhibitors on Pro-B Cells-Induced Apoptosis

Gentimir, Carmen; Tatarciuc, Diana; Zaharia, Catalina Anda; Chelaru, Liliana; Costin, Andreea; Jitareanu, Alexandra; Bejinariu, Costica; Costuleanu, Marcel

Carmen Gentimir, Diana Tatarciuc, Catalina Anda Zaharia, Liliana Chelaru, Andreea Costin, Alexandra Jitareanu, Costica Bejinariu, Marcel Costuleanu

Biochemical Effects of Some Tyrosine Kinase Inhibitors on Pro-B Cells-Induced Apoptosis

Abstract:

The present studies aimed the effects of tyrphostin AG 494 and tyrphostin AG 1295 on apoptosis of mouse pro-B lymphocytes. The actual scientific literature lacks such data. Tyrphostin AG 494 is an inhibitor of epidermal growth factor receptor pathways and tyrphostin AG 1295 is an inhibitor of platelet-derived growth factor receptor pathways. Our obtained data demonstrated that tyrphostin AG 1295 was less effective in preventing the apoptosis of murine pro-B cells, triggered by the combination of Cytoporone B (NR4A1 agonist) and Cyclosporine A. In contrast, tyrphostin AG 494 had a stronger inhibitory effect on the apoptosis of the same cells, when administered for 24 hours. Thus, when blocking the activation of epidermal growth factor receptor pathways, the inductive apoptotic effects of Cytoporone B and Cyclosporine A are reduced. Thus, we could conclude that such inhibition will increase the resistance to apoptosis of pro-B cells. Thus, such a resistance to apoptosis could be experimentally acquired by hematopoietic cells.

Keywords:
tyrphostin AG 494; tyrphostin AG 1295; pro-B cells; apoptosis

Issue: 2017, Volume 68, Issue 8

Pages: 1864-1867

Publication date: 2017/9/15

https://doi.org/10.37358/RC.17.8.5781

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
GENTIMIR, C., TATARCIUC, D., ZAHARIA, C.A., CHELARU, L., COSTIN, A., JITAREANU, A., BEJINARIU, C., COSTULEANU, M., Biochemical Effects of Some Tyrosine Kinase Inhibitors on Pro-B Cells-Induced Apoptosis, Rev. Chim., 68(8), 2017, 1864-1867.

Vancouver
Gentimir C, Tatarciuc D, Zaharia CA, Chelaru L, Costin A, Jitareanu A, Bejinariu C, Costuleanu M. Biochemical Effects of Some Tyrosine Kinase Inhibitors on Pro-B Cells-Induced Apoptosis. Rev. Chim.[internet]. 2017 Aug;68(8):1864-1867. Available from: https://doi.org/10.37358/RC.17.8.5781

APA 6th edition
Gentimir, C., Tatarciuc, D., Zaharia, C.A., Chelaru, L., Costin, A., Jitareanu, A., Bejinariu, C. & Costuleanu, M. (2017). Biochemical Effects of Some Tyrosine Kinase Inhibitors on Pro-B Cells-Induced Apoptosis. Revista de Chimie, 68(8), 1864-1867. https://doi.org/10.37358/RC.17.8.5781

Harvard
Gentimir, C., Tatarciuc, D., Zaharia, C.A., Chelaru, L., Costin, A., Jitareanu, A., Bejinariu, C., Costuleanu, M. (2017). 'Biochemical Effects of Some Tyrosine Kinase Inhibitors on Pro-B Cells-Induced Apoptosis', Revista de Chimie, 68(8), pp. 1864-1867. https://doi.org/10.37358/RC.17.8.5781

IEEE
C. Gentimir, D. Tatarciuc, C.A. Zaharia, L. Chelaru, A. Costin, A. Jitareanu, C. Bejinariu, M. Costuleanu, "Biochemical Effects of Some Tyrosine Kinase Inhibitors on Pro-B Cells-Induced Apoptosis". Revista de Chimie, vol. 68, no. 8, pp. 1864-1867, 2017. [online]. https://doi.org/10.37358/RC.17.8.5781

Text
Carmen Gentimir, Diana Tatarciuc, Catalina Anda Zaharia, Liliana Chelaru, Andreea Costin, Alexandra Jitareanu, Costica Bejinariu, Marcel Costuleanu,
Biochemical Effects of Some Tyrosine Kinase Inhibitors on Pro-B Cells-Induced Apoptosis,
Revista de Chimie,
Volume 68, Issue 8,
2017,
Pages 1864-1867,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.8.5781.
(https://revistadechimie.ro/Articles.asp?ID=5781)
Keywords: tyrphostin AG 494; tyrphostin AG 1295; pro-B cells; apoptosis

RIS
TY - JOUR
T1 - Biochemical Effects of Some Tyrosine Kinase Inhibitors on Pro-B Cells-Induced Apoptosis
A1 - Gentimir, Carmen
A2 - Tatarciuc, Diana
A3 - Zaharia, Catalina Anda
A4 - Chelaru, Liliana
A5 - Costin, Andreea
A6 - Jitareanu, Alexandra
A7 - Bejinariu, Costica
A8 - Costuleanu, Marcel
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 8
SP - 1864
EP - 1867
UR - https://doi.org/10.37358/RC.17.8.5781
KW - tyrphostin AG 494
KW - tyrphostin AG 1295
KW - pro-B cells
KW - apoptosis
ER -

BibTex
@article{RevCh2017P1864,
author = {Gentimir Carmen and Tatarciuc Diana and Zaharia Catalina Anda and Chelaru Liliana and Costin Andreea and Jitareanu Alexandra and Bejinariu Costica and Costuleanu Marcel},
title = {Biochemical Effects of Some Tyrosine Kinase Inhibitors on Pro-B Cells-Induced Apoptosis},
journal = {Revista de Chimie},
volume = {68},
number = {8},
pages = {1864-1867},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.8.5781},
url = {https://revistadechimie.ro/Articles.asp?ID=5781}
}

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