TNF Inhibitors and Periodontal Inflammation in Psoriatic Arthritis

Ancuta, Codrina; Ancuta, Eugen; Chirieac, Rodica; Anton, Carmen; Surlari, Zenaida; Iordache, Cristina

Codrina Ancuta, Eugen Ancuta, Rodica Chirieac, Carmen Anton, Zenaida Surlari, Cristina Iordache

TNF Inhibitors and Periodontal Inflammation in Psoriatic Arthritis

Abstract:

The link between immune mediated rheumatic disorders and oral health, particularly periodontal disease, is widely accepted, based on shared immune and inflammatory processes as well as local (articular, gingival) damage mediated by similar pro-inflammatory cytokine and destructive mediators. We aimed to evaluate periodontal status in psoriatic arthritis (PsA) before and after 24-weeks treatment with TNF inhibitors and to identify potential relation between disease activity, inflammatory parameters, therapeutic response and chronic periodontitis. Patients were prospectively assessed according to a standard protocol comprising a complex rheumatologic (PsA activity, inflammatory prolife) and dental evaluation (plaque and gingival index, bleeding on probing, periodontal pocket depth, clinical attachment level). Up to one third PsA presented with moderate to severe periodontitis at baseline, with high prevalence of sites with dental plaque, abnormal bleeding, increased periodontal pocket depth and clinical attachment loss. Higher levels of inflammatory parameters were described in the subset of PsA presenting with aggressive periodontal diseases, while significant correlation between dental pathology and CRP (p[0.05). A significant improvement in both PsA-related parameters and periodontal status was demonstrated after 24 weeks of anti-TNF therapy (p[0.05). Periodontal disease may develop in PsA and should be commonly evaluated, particularly patients with active disease. Benefits of TNF inhibitors, with significant response in articular and periodontal parameters, suggest common inflammatory pathways in both entities.

Keywords:
psoriatic arthritis; periodontal disease; TNF inhibitors

Issue: 2017, Volume 68, Issue 8

Pages: 1914-1918

Publication date: 2017/9/15

https://doi.org/10.37358/RC.17.8.5790

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ANCUTA, C., ANCUTA, E., CHIRIEAC, R., ANTON, C., SURLARI, Z., IORDACHE, C., TNF Inhibitors and Periodontal Inflammation in Psoriatic Arthritis, Rev. Chim., 68(8), 2017, 1914-1918.

Vancouver
Ancuta C, Ancuta E, Chirieac R, Anton C, Surlari Z, Iordache C. TNF Inhibitors and Periodontal Inflammation in Psoriatic Arthritis. Rev. Chim.[internet]. 2017 Aug;68(8):1914-1918. Available from: https://doi.org/10.37358/RC.17.8.5790

APA 6th edition
Ancuta, C., Ancuta, E., Chirieac, R., Anton, C., Surlari, Z. & Iordache, C. (2017). TNF Inhibitors and Periodontal Inflammation in Psoriatic Arthritis. Revista de Chimie, 68(8), 1914-1918. https://doi.org/10.37358/RC.17.8.5790

Harvard
Ancuta, C., Ancuta, E., Chirieac, R., Anton, C., Surlari, Z., Iordache, C. (2017). 'TNF Inhibitors and Periodontal Inflammation in Psoriatic Arthritis', Revista de Chimie, 68(8), pp. 1914-1918. https://doi.org/10.37358/RC.17.8.5790

IEEE
C. Ancuta, E. Ancuta, R. Chirieac, C. Anton, Z. Surlari, C. Iordache, "TNF Inhibitors and Periodontal Inflammation in Psoriatic Arthritis". Revista de Chimie, vol. 68, no. 8, pp. 1914-1918, 2017. [online]. https://doi.org/10.37358/RC.17.8.5790

Text
Codrina Ancuta, Eugen Ancuta, Rodica Chirieac, Carmen Anton, Zenaida Surlari, Cristina Iordache,
TNF Inhibitors and Periodontal Inflammation in Psoriatic Arthritis,
Revista de Chimie,
Volume 68, Issue 8,
2017,
Pages 1914-1918,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.8.5790.
(https://revistadechimie.ro/Articles.asp?ID=5790)
Keywords: psoriatic arthritis; periodontal disease; TNF inhibitors

RIS
TY - JOUR
T1 - TNF Inhibitors and Periodontal Inflammation in Psoriatic Arthritis
A1 - Ancuta, Codrina
A2 - Ancuta, Eugen
A3 - Chirieac, Rodica
A4 - Anton, Carmen
A5 - Surlari, Zenaida
A6 - Iordache, Cristina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 8
SP - 1914
EP - 1918
UR - https://doi.org/10.37358/RC.17.8.5790
KW - psoriatic arthritis
KW - periodontal disease
KW - TNF inhibitors
ER -

BibTex
@article{RevCh2017P1914,
author = {Ancuta Codrina and Ancuta Eugen and Chirieac Rodica and Anton Carmen and Surlari Zenaida and Iordache Cristina},
title = {TNF Inhibitors and Periodontal Inflammation in Psoriatic Arthritis},
journal = {Revista de Chimie},
volume = {68},
number = {8},
pages = {1914-1918},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.8.5790},
url = {https://revistadechimie.ro/Articles.asp?ID=5790}
}

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