The Effect of Exercising on Oxidative Stress Status and Pain in a Valproic-acid Induced Model of Autism Possible relevance of oxytocin

Antioch, Iulia; Ababei, Dana; Lefter, Radu; Ciobica, Alin; Honceriu, Cezar; Bild, Veronica

Iulia Antioch, Dana Ababei, Radu Lefter, Alin Ciobica, Cezar Honceriu, Veronica Bild

The Effect of Exercising on Oxidative Stress Status and Pain in a Valproic-acid Induced Model of Autism Possible relevance of oxytocin

Abstract:

In this report we will describe the effect of exercising (6 days, each day 3 separate training phases of 5 minutes each, on an adapted treadmill at 1.0 m/s) on oxidative stress status from the temporal lobe (expressed through 3 main parameters: superoxide dismutase (SOD), glutathione peroxidase (GPX) and malondialdehyde (MDA), as a marker of lipid peroxidation) and pain (as determined through 2 specific behavioural tasks such as hot plate test for the supraspinal acute thermal pain and the intra abdominal Zymosan administration for eliciting a local inflammatory reaction following responses to inflammatory visceral pain) in a rat valproic-acid induced perinatal model of autism, also trying to emphasize a possible implication of oxytocin in this complex pathological picture. We demonstrated here an increased oxidative stress status, as a result of treadmill exercising, in a VPA rat induced model of autism, as demonstrated mainly by a significant decrease in the specific activity of SOD (for the exercised VPA female rats), as well as a significant decrease of GPX specific activity in the male VPA exercised rats, when compared to non-exercised VPA groups, as well as the fact that the aforementioned series of exercises did not resulted in any changes of the pain perception of this rat models of autism, as studied in 2 pain-related behavioural tasks, independent to the gender of the rats with VPA model of autism.

Keywords:
autism; oxidative stress; model; pain; superoxide dismutase; glutathione peroxidase; malondialdehyde

Issue: 2017, Volume 68, Issue 9

Pages: 2028-2033

Publication date: 2017/10/15

https://doi.org/10.37358/RC.17.9.5815

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ANTIOCH, I., ABABEI, D., LEFTER, R., CIOBICA, A., HONCERIU, C., BILD, V., The Effect of Exercising on Oxidative Stress Status and Pain in a Valproic-acid Induced Model of Autism Possible relevance of oxytocin, Rev. Chim., 68(9), 2017, 2028-2033.

Vancouver
Antioch I, Ababei D, Lefter R, Ciobica A, Honceriu C, Bild V. The Effect of Exercising on Oxidative Stress Status and Pain in a Valproic-acid Induced Model of Autism Possible relevance of oxytocin. Rev. Chim.[internet]. 2017 Sep;68(9):2028-2033. Available from: https://doi.org/10.37358/RC.17.9.5815

APA 6th edition
Antioch, I., Ababei, D., Lefter, R., Ciobica, A., Honceriu, C. & Bild, V. (2017). The Effect of Exercising on Oxidative Stress Status and Pain in a Valproic-acid Induced Model of Autism Possible relevance of oxytocin. Revista de Chimie, 68(9), 2028-2033. https://doi.org/10.37358/RC.17.9.5815

Harvard
Antioch, I., Ababei, D., Lefter, R., Ciobica, A., Honceriu, C., Bild, V. (2017). 'The Effect of Exercising on Oxidative Stress Status and Pain in a Valproic-acid Induced Model of Autism Possible relevance of oxytocin', Revista de Chimie, 68(9), pp. 2028-2033. https://doi.org/10.37358/RC.17.9.5815

IEEE
I. Antioch, D. Ababei, R. Lefter, A. Ciobica, C. Honceriu, V. Bild, "The Effect of Exercising on Oxidative Stress Status and Pain in a Valproic-acid Induced Model of Autism Possible relevance of oxytocin". Revista de Chimie, vol. 68, no. 9, pp. 2028-2033, 2017. [online]. https://doi.org/10.37358/RC.17.9.5815

Text
Iulia Antioch, Dana Ababei, Radu Lefter, Alin Ciobica, Cezar Honceriu, Veronica Bild,
The Effect of Exercising on Oxidative Stress Status and Pain in a Valproic-acid Induced Model of Autism Possible relevance of oxytocin,
Revista de Chimie,
Volume 68, Issue 9,
2017,
Pages 2028-2033,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.9.5815.
(https://revistadechimie.ro/Articles.asp?ID=5815)
Keywords: autism; oxidative stress; model; pain; superoxide dismutase; glutathione peroxidase; malondialdehyde

RIS
TY - JOUR
T1 - The Effect of Exercising on Oxidative Stress Status and Pain in a Valproic-acid Induced Model of Autism Possible relevance of oxytocin
A1 - Antioch, Iulia
A2 - Ababei, Dana
A3 - Lefter, Radu
A4 - Ciobica, Alin
A5 - Honceriu, Cezar
A6 - Bild, Veronica
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 9
SP - 2028
EP - 2033
UR - https://doi.org/10.37358/RC.17.9.5815
KW - autism
KW - oxidative stress
KW - model
KW - pain
KW - superoxide dismutase
KW - glutathione peroxidase
KW - malondialdehyde
ER -

BibTex
@article{RevCh2017P2028,
author = {Antioch Iulia and Ababei Dana and Lefter Radu and Ciobica Alin and Honceriu Cezar and Bild Veronica},
title = {The Effect of Exercising on Oxidative Stress Status and Pain in a Valproic-acid Induced Model of Autism Possible relevance of oxytocin},
journal = {Revista de Chimie},
volume = {68},
number = {9},
pages = {2028-2033},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.9.5815},
url = {https://revistadechimie.ro/Articles.asp?ID=5815}
}

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