Lipd Metabolism Abnormalities in Children and Adolescents with HIV/AIDS Treated with Protease Inhibitors

Jugulete, Gheorghita; Iacob, Simona; Merisescu, Madalina; Luminos, Monica

Gheorghita Jugulete, Simona Iacob, Madalina Merisescu, Monica Luminos

Lipd Metabolism Abnormalities in Children and Adolescents with HIV/AIDS Treated with Protease Inhibitors

Abstract:

In this paper we propose to evaluate the lipid metabolism abnormalities in children and adolescents with HIV/AIDS undergoing treatment with protease inhibitors (PIs). There are over 1000 children and adolescents with HIV infection of various stages registered in the Pediatric Department of the National Institute of Infectious Diseases Prof. Dr. Matei Bals. We have carried out a retrospective study on 200 HIV seropositive children without previous lipid metabolism abnormalities in which antiretroviral treatment was initiated. In these patients we have monitored modifications in lipid metabolism secondary to antiretroviral treatment (triglycerides, cholesterol, and lipids). The majorities of abnormalities of the lipid metabolism were not severe and did not require modification or cessation of treatment. 24 months of treatment later, approximately 23.5% of patients treated with 2 NRTI+PI/r had modifications of the lipid metabolism: 34.6% had hypercholesterolemia, 38.4% had hypertriglyceridemia, and 36.9% had an increase of total serum lipids. Lipid metabolism abnormalities have been more significant in patients treated previously with antiretrovirals, especially those who have received PIs, in comparison to naïve patients.

Keywords:
lipid metabolism modifications; HIV; child

Issue: 2017, Volume 68, Issue 10

Pages: 2467-2470

Publication date: 2017/11/15

https://doi.org/10.37358/RC.17.10.5907

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
JUGULETE, G., IACOB, S., MERISESCU, M., LUMINOS, M., Lipd Metabolism Abnormalities in Children and Adolescents with HIV/AIDS Treated with Protease Inhibitors, Rev. Chim., 68(10), 2017, 2467-2470.

Vancouver
Jugulete G, Iacob S, Merisescu M, Luminos M. Lipd Metabolism Abnormalities in Children and Adolescents with HIV/AIDS Treated with Protease Inhibitors. Rev. Chim.[internet]. 2017 Oct;68(10):2467-2470. Available from: https://doi.org/10.37358/RC.17.10.5907

APA 6th edition
Jugulete, G., Iacob, S., Merisescu, M. & Luminos, M. (2017). Lipd Metabolism Abnormalities in Children and Adolescents with HIV/AIDS Treated with Protease Inhibitors. Revista de Chimie, 68(10), 2467-2470. https://doi.org/10.37358/RC.17.10.5907

Harvard
Jugulete, G., Iacob, S., Merisescu, M., Luminos, M. (2017). 'Lipd Metabolism Abnormalities in Children and Adolescents with HIV/AIDS Treated with Protease Inhibitors', Revista de Chimie, 68(10), pp. 2467-2470. https://doi.org/10.37358/RC.17.10.5907

IEEE
G. Jugulete, S. Iacob, M. Merisescu, M. Luminos, "Lipd Metabolism Abnormalities in Children and Adolescents with HIV/AIDS Treated with Protease Inhibitors". Revista de Chimie, vol. 68, no. 10, pp. 2467-2470, 2017. [online]. https://doi.org/10.37358/RC.17.10.5907

Text
Gheorghita Jugulete, Simona Iacob, Madalina Merisescu, Monica Luminos,
Lipd Metabolism Abnormalities in Children and Adolescents with HIV/AIDS Treated with Protease Inhibitors,
Revista de Chimie,
Volume 68, Issue 10,
2017,
Pages 2467-2470,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.10.5907.
(https://revistadechimie.ro/Articles.asp?ID=5907)
Keywords: lipid metabolism modifications; HIV; child

RIS
TY - JOUR
T1 - Lipd Metabolism Abnormalities in Children and Adolescents with HIV/AIDS Treated with Protease Inhibitors
A1 - Jugulete, Gheorghita
A2 - Iacob, Simona
A3 - Merisescu, Madalina
A4 - Luminos, Monica
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 10
SP - 2467
EP - 2470
UR - https://doi.org/10.37358/RC.17.10.5907
KW - lipid metabolism modifications
KW - HIV
KW - child
ER -

BibTex
@article{RevCh2017P2467,
author = {Jugulete Gheorghita and Iacob Simona and Merisescu Madalina and Luminos Monica},
title = {Lipd Metabolism Abnormalities in Children and Adolescents with HIV/AIDS Treated with Protease Inhibitors},
journal = {Revista de Chimie},
volume = {68},
number = {10},
pages = {2467-2470},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.10.5907},
url = {https://revistadechimie.ro/Articles.asp?ID=5907}
}

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